Analysis of Risk Factors of Chronic Pulmonary Heart Disease in Patients With Pneumoconiosis

CHEN Qing; ZHANG Peng; CHEN Xuxi; ZOU Yanqiu; LIAO Jiaqiang; ZHANG Qin; PENG Lijun; LAN Yajia; YAO Yuqin; HE Qiurong

doi:10.12182/20240160107

Volume 55 Issue 1

Jan. 2024

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JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES) > 2024 > 55(1): 167-175. > DOI: 10.12182/20240160107

CHEN Qing, ZHANG Peng, CHEN Xuxi, et al. Analysis of Risk Factors of Chronic Pulmonary Heart Disease in Patients With Pneumoconiosis[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(1): 167-175. DOI: 10.12182/20240160107

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Analysis of Risk Factors of Chronic Pulmonary Heart Disease in Patients With Pneumoconiosis

CHEN Qing^{1, 2,},
ZHANG Peng^{2, 3},
CHEN Xuxi^{2, 4},
ZOU Yanqiu^{2, 3},
LIAO Jiaqiang^{2, 3},
ZHANG Qin^{1, 2},
PENG Lijun^{2, 5, 6},
LAN Yajia^{1, 2, 6},
YAO Yuqin^{1, 2, 4, 6},
HE Qiurong^{6, 7, ,}

1.
Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
2.
West China Occupational Pneumoconiosis Cohort Study (WCOPCS) Work Group, Chengdu 610041, China
3.
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
4.
Department of Health Toxicology and Pathology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
5.
Department of Respiratory Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
6.
West China-PUMC C. C. Chen Institute of Health, Chengdu 610041, China
7.
Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China

More Information

Corresponding author:
HE Qiurong, E-mail: heqiurong2009@163.com
Received Date: August 24, 2023
Revised Date: January 10, 2024
Published Date: January 19, 2024

Abstract

Abstract

Objective
To explore the risk factors for developing chronic pulmonary heart disease in patients with pneumoconiosis.
Methods
The medical records of pneumoconiosis patients admitted to an occupational disease hospital in Sichuan Province between January 2012 and November 2021 were collected. Kaplan-Meier (K-M) method, or product-limit method, was used to plot the incidence curves of pulmonary heart disease in the pneumoconiosis patients. Cox proportional hazard regression model was used to analyze the influencing factors associated with chronic pulmonary heart disease in patients with pneumoconiosis.
Results
A total of 885 pneumoconiosis patients were included in this study. The follow-up time was 12 to 115 months and the median follow-up time was 43 months. A total of 138 patients developed chronic pulmonary heart disease and the incidence density of pulmonary heart disease was 38.50/1000 person-years. Multivariate Cox proportional hazard regression analysis showed that the influencing factors of pneumoconiosis inpatients developing chronic pulmonary heart disease included the following, being 50 and older (hazard ratio [HR]=1.85, 95% confidence interval [CI]: 1.25-2.74), stage Ⅲ pneumoconiosis (HR=2.43, 95% CI: 1.48-4.01), resting heart rate≥100 beats/min (HR=2.62, 95% CI: 1.63-4.21), the complication of chronic obstructive pulmonary disease (COPD) (HR=4.52, 95% CI: 2.12-9.63), underweight (HR=2.40, 95% CI: 1.48-3.87), overweight and obesity (HR=0.54, 95% CI: 0.34-0.86), and triacylglycerol (TG) (HR=0.69, 95% CI: 0.49-0.99).
Conclusion
Old age, stage Ⅲ pneumoconiosis, high resting heart rate, low BMI, and the complication of COPD are risk factors for chronic pulmonary heart disease in pneumoconiosis patients, while overweight and obesity and TG are protective factors. Early identification of the risk factors and the adoption of the corresponding prevention measures are the key to preventing chronic pulmonary heart disease in patients with pneumoconiosis.
- Pneumoconiosis,
- Pulmonary heart disease,
- Risk factors,
- Retrospective study

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References (24)

References

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