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LIN Gongchao, TENG Fei, HU Qiaozhi, et al. Knowledge Graph-Based Prediction of Potentially Inappropriate Medication[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(5): 884-891. DOI: 10.12182/20230960108
Citation: LIN Gongchao, TENG Fei, HU Qiaozhi, et al. Knowledge Graph-Based Prediction of Potentially Inappropriate Medication[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(5): 884-891. DOI: 10.12182/20230960108

Knowledge Graph-Based Prediction of Potentially Inappropriate Medication

  •   Objective  To improve the accuracy of potentially inappropriate medication (PIM) prediction, a PIM prediction model that combines knowledge graph and machine learning was proposed.
      Methods  Firstly, based on Beers criteria 2019 and using the knowledge graph as the basic structure, a PIM knowledge representation framework with logical expression capabilities was constructed, and a PIM inference process was implemented from patient information nodes to PIM nodes. Secondly, a machine learning prediction model for each PIM label was established based on the classifier chain algorithm, to learn the potential feature associations from the data. Finally, based on a threshold of sample size, a portion of reasoning results from the knowledge graph was used as output labels on the classifier chain to enhance the reliability of the prediction results of low-frequency PIMs.
      Results  11741 prescriptions from 9 medical institutions in Chengdu were used to evaluate the effectiveness of the model. Experimental results show that the accuracy of the model for PIM quantity prediction is 98.10%, the F1 is 93.66%, the Hamming loss for PIM multi-label prediction is 0.06%, and the macroF1 is 66.09%, which has higher prediction accuracy than the existing models.
      Conclusion  The method proposed has better prediction performance for potentially inappropriate medication and significantly improves the recognition of low-frequency PIM labels.
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