Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia

DENG Li-hong; WEI Wei; QIAO Chun-xia; YIN Yu-bing; JIAN Ling-qi; LI Tao

doi:10.12182/20230360103

Volume 54 Issue 2

Mar. 2023

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JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES) > 2023 > 54(2): 281-286. > DOI: 10.12182/20230360103

DENG Li-hong, WEI Wei, QIAO Chun-xia, et al. Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(2): 281-286. DOI: 10.12182/20230360103

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Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia

1.
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
2.
Affiliated Mental Health Center, Zhejiang University School of Medicine & Hangzhou Seventh People's Hospital, Hangzhou 310013, China

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Corresponding author:
WEI Wei, E-mail: weiqi77777@foxmail.com
Received Date: October 26, 2022
Revised Date: February 01, 2023
Available Online: March 19, 2023
Published Date: March 19, 2023

Abstract

Abstract

Objective To investigate frequency-specific alterations of spontaneous brain activity in first-episode drug-naïve schizophrenia (SZ) patients and the associations with clinical symptoms.
Methods We collected the resting-state functional MRI (rs-fMRI) data from 84 first-episode drug-naïve SZ patients and 94 healthy controls (HCs) and calculated the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) of four frequency bands, including slow-2, slow-3, slow-4, and slow-5. Two-sample t-tests were used to evaluate the intergroup differences in ALFF and ReHo, while partial correlation analyses were conducted to explore the associations between abnormal ALFF and ReHo and the severity of clinical symptoms in the SZ group.
Results Compared with HCs, the SZ group showed reduced ALFF in superior cerebellum and cerebellar vermis across slow-2, slow-3, and slow-4 bands, while increased ALFF was found in left superior temporal gyrus, middle temporal gyrus, and superior temporal pole at slow-4 band. Moreover, reduced ReHo was observed in the right precentral and postcentral gyri at slow-3 band in the SZ group. Additionally, the ALFF of left superior temporal gyrus, middle temporal gyrus, and superior temporal pole in slow-4 band showed a trend of positive correlation with the excited factor score of Positive and Negative Syndrome Scale (PANSS) in the SZ group.
Conclusion Our results suggest that local alterations of spontaneous brain activity were frequency-specific in first-episode drug-naïve SZ patients.
- Schizophrenia,
- Spontaneous brain activity,
- Frequency-specific,
- Amplitude of low-frequency fluctuations,
- Regional homogeneity

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Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Naïve Schizophrenia

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