Welcome to JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES) June 2, 2025
CHEN Qiu-he, CHEN Qian, ZHANG Lin, et al. Relationship Between ABO Blood Group and Pregnancy Complications[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(5): 935-940. DOI: 10.12182/20220960304
Citation: CHEN Qiu-he, CHEN Qian, ZHANG Lin, et al. Relationship Between ABO Blood Group and Pregnancy Complications[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(5): 935-940. DOI: 10.12182/20220960304

Relationship Between ABO Blood Group and Pregnancy Complications

More Information
  • Corresponding author:

    HU Ya-yi, E-mail: yayi.hu@163.com

  • Received Date: January 09, 2022
  • Revised Date: August 13, 2022
  • Available Online: September 25, 2022
  • Published Date: September 19, 2022
  • ABO blood group system is the most commonly used blood group classification system in clinic practice. The relevant antigens, A, B and H determinants, are complex carbohydrate molecules that are expressed in red blood cells and other cell lines and tissues. These antigens are determined by the ABO locus located on chromosome 9 (9q34.1-q34.2). ABO blood group is associated with the development of many human diseases, e.g., cardiovascular diseases, infectious diseases, and tumors. The relationship between the ABO blood group of pregnant women and various pregnancy complications, including preeclampsia (PE) and the related diseases, pregnancy associated venous thromboembolism (PA-VTE), gestational diabetes mellitus (GDM), and postpartum hemorrhage (PPH), have become the focus of obstetricians' recent research interest. Herein, we reviewed the relationship between ABO blood group and these pregnancy complications, and found that most of the reported findings supported the following views: 1) Blood type O is a protective factor for PE, while blood type AB increases the risk of PE; 2) blood types other than O are more prone to PA-VTE than blood type O; 3) blood type O or blood type AB may be related to the pathogenesis of GDM; 4) women of blood type O are at higher risks for PPH than those of other blood types. More in-depth epidemiological and genetic studies are needed to confirm these findings in the future. These findings can provide new ideas for researching into the pathogenesis of obstetric diseases and form the theoretical basis for obstetricians to prevent and treat related diseases.
  • [1]
    GOUMIDI L, THIBORD F, WIGGINS K L, et al. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. Blood,2021,137(17): 2394–2402. DOI: 10.1182/blood.2020008997
    [2]
    IBRAHIM-KOSTA M, BAILLY P, SILVY M, et al. ABO blood group, glycosyltransferase activity and risk of venous thromboembolism. Thromb Res,2020,193: 31–35. DOI: 10.1016/j.thromres.2020.05.051
    [3]
    FRANCHINI M, MENGOLI C, LIPPI G. Relationship between ABO blood group and pregnancy complications: A systematic literature analysis. Blood Transfus,2016,14(5): 441–448. DOI: 10.2450/2016.0313-15
    [4]
    ACOG Practice Bulletin No. 202: Gestational hypertension and preeclampsia. Obstet Gynecol, 2019, 133(1): 1[2022-03-29]. https://sci1.tongyongbei.com/10.1097/AOG.0000000000003018. doi: 10.1097/AOG.0000000000003018.
    [5]
    MOL B W J, ROBERTS C T, THANGARATINAM S, et al. Pre-eclampsia. Lancet,2016,387(10022): 999–1011. DOI: 10.1016/S0140-6736(15)00070-7
    [6]
    SAY L, CHOU D, GEMMILL A, et al. Global causes of maternal death: A WHO systematic analysis. Lancet Glob Health. 2014, 2(6): e323−e333[2022-03-29]. https://doi.org/10.1016/S2214-109X(14)70227-X.
    [7]
    ALPOIM P N, DE BARROS PINHEIRO M, JUNQUEIRA D R G, et al. Preeclampsia and ABO blood groups: A systematic review and meta-analysis. Mol Biol Rep,2013,40(3): 2253–2261. DOI: 10.1007/s11033-012-2288-2
    [8]
    AVCI D, KARAGOZ H, OZER O, et al. Are the blood groups of women with preeclampsia a risk factor for the development of hypertension postpartum? Ther Clin Risk Manag,2016,12: 617–622. DOI: 10.2147/TCRM.S100557
    [9]
    AGHASADEGHI F, SAADAT M. Association between ABO and Rh blood groups and risk of preeclampsia: A case-control study from Iran. Open Access Maced J Med Sci,2017,5(2): 173–176. DOI: 10.3889/oamjms.2017.002
    [10]
    OKOYE H, EFOBI C, UGWU A, et al. ABO blood group as a biomarker of preeclampsia among antenatal clinic attendees in Nigeria. Niger J Clin Pract,2020,23(5): 729–733. DOI: 10.4103/njcp.njcp_48_19
    [11]
    MAHASUB N, BORIBOONHIRUNSARN D. Relationship between ABO blood groups and preeclampsia. Hypertens Pregnancy,2020,39(3): 348–353. DOI: 10.1080/10641955.2020.1777298
    [12]
    LI T, WANG Y, WU L, et al. The association between ABO blood group and preeclampsia: A systematic review and meta-analysis. Front Cardiovasc Med, 2021, 8: 665069[2022-03-29]. https://sci1.tongyongbei.com/10.3389/fcvm.2021.665069. doi: 10.3389/fcvm.2021.665069.
    [13]
    THAN N G, ROMERO R, MEIRI H, et al. PP13, maternal ABO blood groups and the risk assessment of pregnancy complications. PLoS One, 2011, 6(7): e21564[2022-03-29]. https://sci1.tongyongbei.com/10.1371/journal.pone.0021564. doi: 10.1371/journal.pone.0021564.
    [14]
    ALPOIM P N, GOMES K B, GODOI L C, et al. ADAMTS13, FⅧ, von Willebrand factor, ABO blood group assessment in preeclampsia. Clin Chim Acta,2011,412(23/24): 2162–2166. DOI: 10.1016/j.cca.2011.07.030
    [15]
    XIAO J, FENG Y, LI X, et al. Expression of ADAMTS13 in normal and abnormal placentae and its potential role in angiogenesis and placenta development. Arterioscler Thromb Vasc Biol,2017,37(9): 1748–1756. DOI: 10.1161/ATVBAHA.117.309735
    [16]
    PHALOPRAKARN C, TANGJITGAMOL S. Maternal ABO blood group and adverse pregnancy outcomes. J Perinatol,2013,33(2): 107–111. DOI: 10.1038/jp.2012.73
    [17]
    SEZIK M, TOYRAN H, YAPAR E G. Distribution of ABO and Rh blood groups in patients with HELLP syndrome. Arch Gynecol Obstet,2002,267(1): 33–36. DOI: 10.1007/s00404-001-0263-6
    [18]
    BURGESS A, JOHNSON T S, SIMANEK A, et al. Maternal ABO blood type and factors associated with preeclampsia subtype. Biol Res Nurs,2019,21(3): 264–271. DOI: 10.1177/1099800419833782
    [19]
    CLARK P, GREER I A. The influence of maternal Lewis, Secretor and ABO(H) blood groups on fetal growth restriction. J Thromb Haemost,2011,9(12): 2411–2415. DOI: 10.1111/j.1538-7836.2011.04515.x
    [20]
    DENTALI F, SIRONI A, AGENO W, et al. Non-O blood type is the commonest genetic risk factor for VTE: Results from a meta-analysis of the literature. Semin Thromb Hemost,2012,38(5): 535–548. DOI: 10.1055/s-0032-1315758
    [21]
    SUN X, FENG J, WU W, et al. ABO blood types associated with the risk of venous thromboembolism in Han Chinese people: A hospital-based study of 200, 000 patients. Sci Rep, 2017, 7: 42925[2022-03-29]. https://sci1.tongyongbei.com/10.1038/srep42925. doi: 10.1038/srep42925.
    [22]
    GANDARA E, KOVACS M J, KAHN S R, et al. Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study. Thromb Haemost,2013,110(6): 1172–1179. DOI: 10.1160/TH13-06-0488
    [23]
    KIECHL S, PARÉ G, BARBALIC M, et al. Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin. Circ Cardiovasc Genet,2011,4(6): 681–686. DOI: 10.1161/CIRCGENETICS.111.960682
    [24]
    ALBÁNEZ S, OGIWARA K, MICHELS A, et al. Aging and ABO blood type influence von Willebrand factor and factor Ⅷ levels through interrelated mechanisms. J Thromb Haemost,2016,14(5): 953–963. DOI: 10.1111/jth.13294
    [25]
    DE HAAN H G, BEZEMER I D, DOGGEN C J, et al. Multiple SNP testing improves risk prediction of first venous thrombosis. Blood,2012,120(3): 656–663. DOI: 10.1182/blood-2011-12-397752
    [26]
    AHMAD A, SUNDQUIST K, PALMER K, et al. Risk prediction of recurrent venous thromboembolism: A multiple genetic risk model. J Thromb Thrombolysis,2019,47(2): 216–226. DOI: 10.1007/s11239-018-1762-7
    [27]
    LARSEN T B, JOHNSEN S P, GISLUM M, et al. ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium. A population-based, nested case-control study. J Thromb Haemost,2005,3(2): 300–304. DOI: 10.1111/j.1538-7836.2005.01195.x
    [28]
    WANG C, LE RAY I, LEE B, et al. Association of blood group and red blood cell transfusion with the incidence of antepartum, peripartum and postpartum venous thromboembolism. Sci Rep, 2019, 9(1): 13535[2022-03-29]. https://sci1.tongyongbei.com/10.1038/s41598-019-49566-3. doi: 10.1038/s41598-019-49566-3.
    [29]
    CANO E A, ESGUERRA M A, BATAUSA A M, et al. Association between ABO blood groups and type 2 diabetes mellitus: A meta-analysis. Curr Diabetes Rev, 2022[2022-04-27]. https://sci1.tongyongbei.com/10.2174/1573399818666220427124448. doi: 10.2174/1573399818666220427124448.
    [30]
    SEYFIZADEH N, SEYFIZADEH N, YOUSEFI B, et al. Is there association between ABO blood group and the risk factors of unfavorable outcomes of pregnancy? J Matern Fetal Neonatal Med,2014,28(5): 578–582. DOI: 10.3109/14767058.2014.927424
    [31]
    DONMA M M. Macrosomia, top of the iceberg: The charm of underlying factors. Pediatr Int,2011,53(1): 78–84. DOI: 10.1111/j.1442-200X.2010.03198.x
    [32]
    SAPANONT K, SUNSANEEVITHAYAKUL P, BORIBOONHIRUNSARN D. Relationship between ABO blood group and gestational diabetes mellitus. J Matern Fetal Neonatal Med,2021,34(8): 1255–1259. DOI: 10.1080/14767058.2019.1633299
    [33]
    ZHANG C, LI Y, WANG L, et al. Blood group AB is protective factor for gestational diabetes mellitus: A prospective population-based study in Tianjin, China. Diabetes Metab Res Rev,2015,31(6): 627–637. DOI: 10.1002/dmrr.2650
    [34]
    ROM E, YOGEV M, SELA N, et al. The association between ABO blood groups and gestational diabetes mellitus: A retrospective population-based cohort study. J Matern Fetal Neonatal Med, 2021: 1−5[2022-03-29]. https://sci1.tongyongbei.com/10.1080/14767058.2021.1941852. doi: 10.1080/14767058.2021.1941852.
    [35]
    SHIMODAIRA M, YAMASAKI T, NAKAYAMA T. The association of maternal ABO blood group with gestational diabetes mellitus in Japanese pregnant women. Diabetes Metab Syndr,2016,10(2): S102–S105. DOI: 10.1016/j.dsx.2016.03.003
    [36]
    KARAGOZ H, ERDEN A, OZER O, et al. The role of blood groups in the development of diabetes mellitus after gestational diabetes mellitus. Ther Clin Risk Manag,2015,11: 1613–1617. DOI: 10.2147/TCRM.S92294
    [37]
    LEMAITRE M, PASSET M, GHESQUIÈRE L, et al. Is the development of gestational diabetes associated with the ABO blood group/rhesus phenotype? Front Endocrinol (Lausanne), 2022, 13: 916903[2022-06-22]. https://sci1.tongyongbei.com/10.3389/fendo.2022.916903. doi: 10.3389/fendo.2022.916903.
    [38]
    SHIBATA-HIRAIZUMI Y, SUZUKI S. Maternal ABO blood group and adverse pregnancy outcomes in Japanese population. J Perinatol,2013,33(9): 743. DOI: 10.1038/jp.2013.81
    [39]
    CHEN D, LIN L, HONG Q, et al. Relationship between ABO blood group and gestational diabetes mellitus: A protocol for systematic review and meta-analysis. Medicine (Baltimore), 2021, 100(19): e25877[2022-03-29]. https://sci1.tongyongbei.com/10.1097/MD.0000000000025877. doi: 10.1097/MD.0000000000025877.
    [40]
    DENTALI F, SIRONI A, AGENO W, et al. Relationship between ABO blood group and hemorrhage: A systematic literature review and meta-analysis. Semin Thromb Hemost,2013,39(1): 72–82. DOI: 10.1055/s-0032-1329550
    [41]
    CHAULEUR C, COCHERY-NOUVELLON E, MERCIER E, et al. Some hemostasis variables at the end of the population distributions are risk factors for severe postpartum hemorrhages. J Thromb Haemost,2008,6(12): 2067–2074. DOI: 10.1111/j.1538-7836.2008.03168.x
    [42]
    DRUKKER L, SREBNIK N, ELSTEIN D, et al. The association between ABO blood group and obstetric hemorrhage. J Thromb Thrombolysis,2016,42(3): 340–345. DOI: 10.1007/s11239-016-1360-5
    [43]
    KAHR M K, FRANKE D, BRUN R, et al. Blood group O: A novel risk factor for increased postpartum blood loss? Haemophilia,2018,24(4): e207–e212. DOI: 10.1111/hae.13537
    [44]
    BADE N A, KAZMA J M, AMDUR R L, et al. Blood type association with bleeding outcomes at delivery in a large multi-center study. J Thromb Thrombolysis,2020,50(2): 439–445. DOI: 10.1007/s11239-019-02023-4
    [45]
    CLARK P, WALKER I D, GOVAN L, et al. The GOAL study: A prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol,2008,140(2): 236–240. DOI: 10.1111/j.1365-2141.2007.06902.x
    [46]
    ALI-SALEH M, LAVIE O, ABRAMOV Y. Evaluation of blood type as a potential risk factor for early postpartum hemorrhage. PLoS One, 2019, 14(4): e214840[2022-03-29]. https://sci1.tongyongbei.com/10.1371/journal.pone.0214840. doi: 10.1371/journal.pone.0214840.
    [47]
    HOBGOOD D K. ABO O gene frequency increase in the US might be causing increased maternal mortality. Med Hypotheses, 2020, 144: 109971[2022-03-29]. https://sci1.tongyongbei.com/10.1016/j.mehy.2020.109971. doi: 10.1016/j.mehy.2020.109971.
    [48]
    MORRIS D S, BRAVERMAN MVA, COREAN J, et al. Whole blood for postpartum hemorrhage: Early experience at two institutions. Transfusion,2020,60(Suppl 3): S31–S35. DOI: 10.1111/trf.15731
    [49]
    BAHR T M, DUPONT T L, MORRIS D S, et al. First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Transfusion,2019,59(10): 3089–3092. DOI: 10.1111/trf.15492
  • Related Articles

    [1]ZENG Fanying, SHEN Ping, GUO Weijie, HE Guolin. Exploring the Causal Relationship Between Coagulation Function and Gestational Diabetes Mellitus Through Mendelian Randomization[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2024, 55(4): 939-946. DOI: 10.12182/20240760301
    [2]TANG Fangmei, BAI Huai, GUAN Linbo, LIU Xinghui, FAN Ping, ZHOU Mi, WU Yujie, LIU Sixu, WANG Yufeng, LI Dehua. Association Between Apolipoprotein C-3 Sst Ⅰ Polymorphism and Serum Lipids in Patients With Gestational Diabetes Mellitus[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(5): 994-999. DOI: 10.12182/20230960505
    [3]LIU Si-xu, BAI Huai, GUAN Lin-bo, LIU Xing-hui, FAN Ping, ZHOU Mi, WU Yu-jie, TANG Fang-mei, WANG Yu-feng, LI De-hua. Cholesterol 7α-Hydroxylase Gene-204A/C Polymorphism in Normal and Gestational Diabetic Pregnancies[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(2): 361-366. DOI: 10.12182/20230160512
    [4]LI Tao, WEI Qiang, WU Lin, CHEN Meng, ZHANG Li-ping, ZHANG Qian, LIU Xing-hui. Multicenter, Randomized, Double-Blind, and Positive Drug-Controlled Clinical Trial on Prevention of Postpartum Hemorrhage after Vaginal Delivery with Ergometrine Maleate[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2022, 53(2): 316-320. DOI: 10.12182/20220360503
    [5]SHI Wei, NIU Xiao-yu, CHEN Yue-yue, WEI Dong-mei, YU Xiao-juan, CHEN Jing, ZHANG Zhi-han, HU Yue, YANG Jie. A Study on the Risk Factors for Early Postpartum Urinary Incontinence in Chengdu[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2019, 50(4): 598-603.
    [6]LIANG Yi, LI Dan-ting, CHEN Meng-xue. et al. Associations of Pre-pregnancy Body Mass Index and Gestational Weight Gain with Gestational Diabetes Mellitus: a Cohort Study in Southwest China[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2019, 50(1): 83-87.
    [7]LI Shu-ying, CHEN Meng, HE Guo-lin. et al. Risk Factors for Blood Transfusion in Women with Postpartum Hemorrhage: a Case-control Study[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2017, 48(6): 937-940.
    [8]LIN Yuan-gui, HUANG Wei. Effects of Tramadol on Insulin Resistance during Cesarean Section Complicated with Gestational Diabetes[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2017, 48(3): 446-449.
    [9]妊娠合并抗NMDA受体脑炎剖宫产1例报告
    [J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2016, 47(3): 450-450.
    [10]ZHANG Mei-qin, LUO HongY。. Three-dimensional Ultrasound of the Pelvic Floor in Early Postpartum after First Delivery[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2016, 47(2): 253-256.
  • Cited by

    Periodical cited type(4)

    1. 段世均,郑谦,石冰,冯帆. 中国西部某三甲医院藏族与汉族唇腭裂患者ABO血型及Rh血型分布研究. 四川大学学报(医学版). 2024(04): 932-938 .
    2. 高倩,卞海艳,李凤文,陈丹,柳鹤,张萌萌,王倩,陈婷. 妊娠期糖尿病患者经阴道分娩会阴伤口愈合的相关影响因素分析. 保健医学研究与实践. 2024(07): 129-133 .
    3. 黄河龙,彭莹,康怀应. 六盘水地区不同民族住院患者红细胞血型及不规则抗体检测分析. 医学信息. 2023(15): 79-83 .
    4. 陈絮,詹玉茹,王纯华. 孕妇ABO血型联合甲状腺功能检测对预测妊娠期糖尿病的临床价值. 中华妇幼临床医学杂志(电子版). 2023(05): 604-610 .

    Other cited types(1)

Catalog

    Article views (922) PDF downloads (118) Cited by(5)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return