Mechanism of Bruch’s Membrane in the Occurrence and Development of Myopia

LI Zhou-yue; YANG Xiao

doi:10.12182/20211160101

Volume 52 Issue 6

Nov. 2021

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JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES) > 2021 > 52(6): 913-916. > DOI: 10.12182/20211160101

LI Zhou-yue, YANG Xiao. Mechanism of Bruch’s Membrane in the Occurrence and Development of Myopia[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(6): 913-916. DOI: 10.12182/20211160101

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Mechanism of Bruch’s Membrane in the Occurrence and Development of Myopia

LI Zhou-yue,
YANG Xiao^,

State Key Laboratory of Ophthalmology and Zhongshan Opthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China

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Corresponding author:
YANG Xiao, E-mail: Yangx_zoc@163.com
Received Date: July 28, 2021
Revised Date: October 08, 2021
Available Online: November 28, 2021
Published Date: November 19, 2021

Abstract

Abstract

Myopia is a process of ocular wall remodeling along with axial elongation after emmetropia decompensation, but the causal relationship among the changes taking place in ocular fundus structures during this process is not clear. The choroid, which lies between the retina and the sclera, plays an important role in the transmission of information related to myopia. The role of choroid in myopia is a hot research topic at present. Findings from animal experiments showed that form deprivation-induced changes in choroidal thickness may be related to the vascular perfusion, but the triggering mechanism of choroidal perfusion changes during the process of myopia still needs to to be further explored. Bruch’s membrane is an elastic membrane located in the front of the choroid with good contractile properties. In the process of myopia, regional changes of the synthesis or biomechanics of Bruch’s membrane may have formed the earliest structural basis of changes in choroidal thickness and blood flow. Taking choroidal thickness as a starting point, this paper focuses on the role and mechanism of Bruch’s membrane in the occurrence and development of myopia, which may further deepen our understanding of the mechanism of changes in choroidal thickness, and provide a theoretical basis for the development of new therapeutic targets for myopia.
- Myopia,
- Choroid,
- Bruch’s membrane,
- Mechanism,
- Children

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Mechanism of Bruch’s Membrane in the Occurrence and Development of Myopia

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