The Risk Factors of Contralateral Central Lymph Node Metastasis in Solitary Thyroid Papillary Micro-carcinoma

Objective To explore the possible risk factors of contralateral central lymph node metastasis（CLNM） in solitary thyroid papillary micro-carcinoma (PTMC). Methods Clinicopathologic data of 318 patients with confirmed solitary PTMC by final histological who underwent bilateral centeral lymph node dissection (CLND)from April 2012 to May 2015 in our hospital were retrospectively reviewed. Univariate χ² test and multivariate logistic regression analysis were used to determine the risk factors of contralateral CLNM in solitary PTMC. Results The incidence of ipsilateral CLNM and contralateral CLNM in solitary PTMC patients were 40.57% (129/318), 9.75% (31/318), respectively. Univariate analyses revealed that contralateral CLNM had a correlation with tumor located in lower pole, capsular invasionand underlying ipsilateral CLNM (P<0.05), and had a correlation with underlying nodular goiter (P<0.05). Multivariate logistic regression analysis showed that tumor located in lower pole and ipsilateral CLNM were independent risk factors for contralateral CLNM (P<0.05). Conclusions Solitary PTMC patients had a lowtendency to contralateral CLNM, it shouldn’t undergo contralateral CLND commonly, if the tumor located in lower pole or combine withipsilateral CLNM, it should be consider to undergo bilateral CLND.