Comparison of MR Perfusion Weighted Imaging and CT Perfusion Imaging in Assessing Hemodynamics of Patients with Moyamoya Disease

Objective To determine consistencies between MR perfusion weighted imaging （PW-MRI） and CT perfusion imaging （CTP） in assessing hemodynamics of patients with moyamoya disease (MMD). Methods Images of PWI and CTP scan 〔including the map of cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transmit time (MTT)〕 of 24 MMD patients diagnosed by digital subtraction angiography(DSA) or time of flight-MR angiography (TOF-MRA) were obtained in the week before vascular reconstruction operations. Relative perfusion parameters （rCBF，rCBV，rMTT，rTTP） at the operative side within the middle cerebral artery territory and cerebellar hemisphere were compared with those of 17 patients without hypoperfusion and cerebrovascular disease using independent sample t test. Paired t test and Pearson correlation analyses were performed between the results of PWI-MRI and CTP. Results Different parameters were found in the MMD patients compared with the controls (P＜0.05). The parameter results of PWI-MRI differed from those of CTP, but they were strongly correlated. Conclusion Both PWI-MRI and CTP can detect the area and degree of hypoperfusion of MMD patients.