中国汉族人群rs12740374单核苷酸多态性与急性缺血性脑卒中的关联性研究

张晶晶; 余丽华; 尹延英; 卢倩; 雷蕾; 肖静; 郭建; 赵晶晶; 王雅楠; 何国倩; 徐严明; 何俐

中国汉族人群rs12740374单核苷酸多态性与急性缺血性脑卒中的关联性研究

Association Between SNP rs12740374 and Acute Ischemic Stroke in Chinese Han Population

摘要

摘要: 目的采用病例-对照研究方式,探讨中国汉族人群中rs12740374基因多态性与缺血性脑卒中的相关关系。方法应用连接酶(LDR)的方法对所有受试者(778例缺血性脑卒中患者及602例对照)进行基因型分型,分析两组间rs12740374位点基因型频率的差异及该位点基因多态性与患者血清低密度脂蛋白胆固醇(LDL-C)浓度的关系。结果卒中组和对照组均检出了GG、GT、TT 3种基因型。运用logistic回归校正多种混杂因素后,结果发现rs12740374基因多态性与缺血性脑卒中无明显关系。携带rs12740374等位基因T的受试者,血清平均LDL-C水平均较GG型受试者低,但差异无统计学意义。结论中国汉族人群中rs12740374位点与缺血性脑卒中之间可能无明确关联;rs12740374可能与不同基因型受试者的LDL-C差异有关。

Abstract: Objective To investigate the association between single nucleotide polymorphism (SNP) rs12740374 and acute ischemic stroke in Chinese Han population. Methods All subjects (778 ischemic stroke patients and 602 controls) were genotyped using ligation detection reaction (LDR). We analyzed the differences among all genotypes in two groups, as well as the association between rs12740374 and low-density lipoprotein cholesterol (LDL-C). Results All three genotypes (GG, GT, TT) of rs12740374 were found in both stroke and control group. After adjusting for risk factors, although there was a trend that participants with a minor allele T of rs12740374 (GT/TT) had lower LDL-C concentration, no significant association was found between rs12740374 and ischemic stroke, and also no significant association between different genotypes and LDL-C was found. Conclusion SNPs of rs12740374 was not significantly associated with ischemic stroke in the Chinese Han population.

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