Abstract: Objective To analyze ultrasonic manifestations of eyes of pediatric patients with morning glory syndrome (MGS). Methods Clinical data and ultrasound (US) findings for six children (4 males and 2 females, 5-60 months old) diagnosed with MGS between 2005 and 2016 were reviewed. Results Of the 12 eyes, seven were diagnosed with MGS; one with cataract; the other four were normal. One child had both eyes diagnosed with MGS. Of the seven eyes with MGS (5 right, 2 left), one was small associated with persistent hyperplastic primary vitreous (PHPV); 2 had retinal detachment. Findings of high frequency ultrasound included local anechoic lesions with distinct boundary showing a convert bottle-neck shape that appeared in the area of optic disk of posterior pole. The lesions communicated with the vitreous caicy and extended to the optic nerves. The lesions had a maximum depth of 4-15 mm 〔(8.29±4.42） mm〕 and a maximum width of 4-11 mm 〔(6.86±2.67） mm〕. Hypoecho material was found in the bottom of five of the seven lesions. The distance between the end of the optic nerves and the bottom of the lesions ranged from 0 to 4.5 mm. Lower levels (Adler 0-1 grade) of blood flow in the bottom of the lesions were found compared with those (3-5 grade) in the rim of the lesions. Conclusion MGS is rare and usual occurs in young children, especially infants. It is often associated with various eye complications. The ultrasound manifestations of MGS are characterized with a local anechoic lesion mimicking a convert bottle-neck shape in the area of optic disk of posterior pole. 