慢性失眠患者的睡眠脑电功率特征

时媛; 任蓉; 张烨; 张海鹏; 谭璐; 周俊英; 孙元锋; 李桃美; 唐向东

doi:10.12182/20220160507

慢性失眠患者的睡眠脑电功率特征

Characteristics of Sleep Electroencephalographic Power in Chronic Insomnia Patients

摘要

摘要:
目的探讨慢性失眠患者的睡眠脑电功率特征。
方法回顾性分析符合ICD-10慢性失眠诊断标准并完成整夜多导睡眠监测（PSG）患者的睡眠脑电资料。比较失眠组和对照组睡眠结构及不同睡眠分期相对脑电功率特征的差异，并进一步分析脑电功率值与不同PSG指标的相关性。
结果共计纳入45例研究对象，其中失眠患者25例（女性18例），年龄（36.2±10.7）岁；对照组20例（女性18例），年龄（36.1±7.6）岁。与对照组相比，失眠组患者NREM1期delta功率降低〔（38.0±6.1） vs. （43.2±5.8），P<0.05〕；NREM期及NREM1期、NREM2期beta功率增高〔NREM期：（5.4±2.3） vs. （3.8±1.4）；NREM1期：（11.3±3.5） vs. （8.7±2.8）；NREM2期：（5.7±2.3） vs. （4.4±1.4）；P均<0.05〕。同时，失眠组患者NREM期delta功率与NREM3期睡眠时间呈正相关(r=0.527)。NREM期beta功率与NREM3期睡眠时间呈负相关(r=−0.767)，与NREM1期、NREM2期睡眠时间呈正相关(r=0.486、0.589)。
结论慢性失眠患者夜间NREM期睡眠中低频脑电功率减少，高频脑电功率增加，研究结果提示慢性失眠患者NREM期睡眠过程中大脑皮质觉醒水平增高。

Abstract:
Objective To study the sleep electroencephalogram (EEG) power features of patients with chronic insomnia.
Methods Retrospective analysis was performed with patients who met the ICD-10 diagnostic criteria for chronic insomnia, using polysomnography (PSG) to examine the overnight sleep EEG. The sleep architectures and relative EEG power across five frequency bands during overnight sleep were compared to study the differences between the insomnia and control groups. Furthermore, the correlation between EEG power and various PSG measures was also analyzed.
Results Forty-five subjects were enrolled in the study, including 25 chronic insomniacs (18 females, aged 36.2±10.7 years) and 20 controls (18 females, aged 36.1±7.6 years). Compared to those of the control group, insomnia patients had significantly lower value of delta power (38.0±6.1 vs. 43.2±5.8, P<0.05) in the NREM1 stage, and increased value of beta power during total NREM, NREM1 and NREM2 (NREM sleep 5.4±2.3 vs. 3.8±1.4, NREM1 11.3±3.5 vs. 8.7±2.8, and NREM2 5.7±2.3 vs. 4.4±1.4, all P<0.05). For correlation analyses, in the insomnia group, a significantly positive correlation was found between the delta value during NREM sleep and the duration of NREM3 sleep (r=0.527). The beta value during NREM sleep was found to be negatively correlated to the duration of NREM3 sleep (r=－0.767). A positive correlation was found between the beta value during NREM sleep and the duration of NREM1 and NREM2 sleep (r=0.486 and 0.589, respectively).
Conclusion The results suggest that patients with chronic insomnia have decreased low-frequency EEG power, but increased high-frequency EEG power during NREM sleep. The findings indicate that cortex arousal level is elevated in chronic insomniacs during NREM sleep.

HTML全文

参考文献(25)

施引文献

资源附件(0)

开放获取 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问 https://creativecommons.org/licenses/by-nc/4.0