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成年女性维生素D水平与握力、平衡能力的相关性分析

黄媛媛, 王覃, 卢春燕, 徐勇, 曹洪义, 谢小华, 吴雪艳, 陈德才

黄媛媛, 王覃, 卢春燕, 等. 成年女性维生素D水平与握力、平衡能力的相关性分析[J]. 四川大学学报（医学版）, 2018, 49(4): 665-669.
引用本文: 黄媛媛, 王覃, 卢春燕, 等. 成年女性维生素D水平与握力、平衡能力的相关性分析[J]. 四川大学学报（医学版）, 2018, 49(4): 665-669.
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HUANG Yuan-yuan, WANG Qin, LU Chun-yan, et al. Association of Serum Vitamin D with Hand-grip Strength and Balance Ability: a Cross-sectional Study on Community-dwelling Women in Sichuan, China[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(4): 665-669.
Citation: HUANG Yuan-yuan, WANG Qin, LU Chun-yan, et al. Association of Serum Vitamin D with Hand-grip Strength and Balance Ability: a Cross-sectional Study on Community-dwelling Women in Sichuan, China[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(4): 665-669.
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栏目: 临床医学

成年女性维生素D水平与握力、平衡能力的相关性分析

  • 1. 四川大学华西医院 内分泌与代谢病科 华西骨质疏松医疗教育中心(成都 610041);

  • 2. 西南医科大学附属医院 内分泌科(泸州 646000);

  • 3. 成都市第五人民医院 内分泌科(成都 611130);

  • 4. 凉山彝族自治州第一人民医院 内分泌科(西昌 615000);

  • 5. 广元市中心医院 内分泌科(广元 628099)

基金项目: 

四川省科技厅科技支撑计划项目（No.2015FZ0079）、四川省科技厅应用基础计划项目（No.2015JY0180）和默克公司MERCK&MSD Investigator Initiated Studies Program（No.MISP-40407）资助

Association of Serum Vitamin D with Hand-grip Strength and Balance Ability: a Cross-sectional Study on Community-dwelling Women in Sichuan, China

  • 1. Department of Endocrinology and Metabolism, Center of Osteoporosis Medicine and Education, West China Hospital, Sichuan University, Chengdu 610041, China;

  • 2. Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;

  • 3. Department of Endocrinology and Metabolism, Chengdu Fifth People's Hospital, Chengdu 611130, China;

  • 4. Department of Endocrinology and Metabolism, First People's Hospital of Yi Autonomous Prefecture of Liangshan, Xichang 615000, China;

  • 5. Department of Endocrinology and Metabolism, Guangyuan Central Hospital, Guangyuan 628099, China

摘要

    摘要
  • 摘要: 目的 探讨中国四川地区成年女性血清25(OH)D、1,25(OH)2D水平与握力、平衡能力的关系。方法 采用横断面调查研究，2012年11月至2013年2月期间，以整群随机抽样法调查了四川地区成都、广元、泸州和西昌共1 095名29~95岁女性。采用手持式测力仪和简易躯体能力测试（简称SPPB测试）评估握力和平衡能力。根据血清25(OH)D水平分为4组：>75 nmol/L为充足， 51~75 nmol/L为不足，25~50 nmol/L为缺乏，<25 nmol/L为严重缺乏。采用一般线性模型校正混杂因素，分析维生素D不同水平分组之间的握力、平衡能力是否有差异，采用logistic多元回归分析25(OH)D、1,25(OH)2D与握力、平衡能力的关系。结果 该人群维生素D缺乏占70.9%，维生素D缺乏或不足的人群多生活在纬度较高的地区（P<0.001），平均户外活动时间少（P=0.013），且食物中未额外补充维生素D制剂（P<0.001）。≥65岁的女性血清25(OH)D水平低于<65岁者（P=0.001），≥65岁女性血清25(OH)D ≤50 nmol/L的比例高于<65岁者（74.6% vs. 68.9%, P=0.046），但两个年龄组血清1,25(OH)2D浓度差异无统计学意义（P=0.610）。按照全年龄段或年龄段分层分析，各维生素D水平分组比较，握力、SPPB总分的差异均无统计学意义。Logistic回归分析提示，随着年龄增长，肌力、平衡能力下降〔比值比（OR)=1.066，P＜0.001；OR=1.111，P＜0.001〕；体质量增加可保持正常善握力（OR=0.958，P<0.001）；血清白蛋白升高（OR=0.896，P=0.001）和增加步行时间（OR=0.799，P=0.001）可保持正常平衡能力。结论 四川地区成年女性血清25(OH)D、1,25(OH)2D水平与握力、平衡能力没有相关性。基于维生素D缺乏现状加强维生素D补充的建议能否改善肌力和平衡能力，还有待进一步研究。

     

    Abstract: Objective To determine the relationship between serum levels of 25(OH)D and 1,25(OH)2 D and the hand-grip strength and balance ability of women in Sichuan, China. Methods A cross-sectional study on a representative sample of 1 095 women aged 29-95 yr. in Sichuan Province was undertaken. Their hand-grip strength and balance ability were assessed using a hand-held dynamometer and the short physical performance battery (SPPB), respectively. The participants were divided into four groups according to the level of serum 25(OH)D: sufficient (>75 nmol/L), insufficient (51-75 nmol/L), deficiency (25-50 nmol/L), and serious deficiency (<25 nmol/L). General liner models were established to compare the differences of the four groups in balance ability. Logistic regression models were established to examine the associations of serum 25(OH)D and 1,25(OH)2 D withhand-grip strength and physical performance. Results About 70.9% of the participants had vitamin D deficiency.

     

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    • 参考文献(15)
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出版历程
  • 收稿日期:  2018-02-10
  • 修回日期:  2018-06-06
  • 发布日期:  2018-07-19

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