欢迎来到《四川大学学报（医学版）》 2025年5月9日 星期五
高级检索

Gαq在多发性肌炎患者外周血T淋巴细胞中的表达及意义

杨闵, 梁燕, 何燕, 左川, 尹耕, 谢其冰

杨闵, 梁燕, 何燕, 等. Gαq在多发性肌炎患者外周血T淋巴细胞中的表达及意义[J]. 四川大学学报（医学版）, 2013, 44(5): 823-826.
引用本文: 杨闵, 梁燕, 何燕, 等. Gαq在多发性肌炎患者外周血T淋巴细胞中的表达及意义[J]. 四川大学学报（医学版）, 2013, 44(5): 823-826.
shu
YANG Min, LIANG Yan, HE Yan, et al. Expression of Gαq in Peripheral Blood T Lymphocytes of Patients with Polymyositis and Its Correlation with Disease Activity[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(5): 823-826.
Citation: YANG Min, LIANG Yan, HE Yan, et al. Expression of Gαq in Peripheral Blood T Lymphocytes of Patients with Polymyositis and Its Correlation with Disease Activity[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(5): 823-826.
shu

栏目: 特发性炎性肌病的临床评估及预后

Gαq在多发性肌炎患者外周血T淋巴细胞中的表达及意义

  • 1. 四川大学华西医院 风湿免疫科(成都 610041);

  • 2. 四川大学华西医院 生物治疗国家重点实验室(成都 610041)

基金项目: 

国家自然科学基金(No.81172869及No.30901339)、四川省科技攻关项目(No.2009SZ0173)和四川省应用基础项目(No.2010JY0011)资助

Expression of Gαq in Peripheral Blood T Lymphocytes of Patients with Polymyositis and Its Correlation with Disease Activity

  • 1. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China;

  • 2. Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

摘要

    摘要
    • HTML全文
    • 参考文献(13)
  • [1]

    Dalakas MC. Review:an update on inflammatory and autoimmune myopathies. Neuropathol Appl Neurobiol,2011;37(3):226-242.
    [2]

    Choi JH, Park YE, Kim SI, et al. Differential immunohistological features of inflammatory myopathies and dysferlinopathy. J Korean Med Sci,2009;24(6):1015-1023.
    [3]

    Hubbard KB, Hepler JR. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cellular Signalling,2006;18(2):135-150.
    [4]

    Wettschureck N, Offermanns S. Mammalian G proteins and their cell type specific functions. Physiol Rev,2005;85(4):1159-1204.
    [5]

    Dalakas MC, Hohlfeld R. Polymyositis and dematomyositis. Lancet,2003;362(9388):971-982.
    [6]

    Rider LG, Giannini EH, Harris-Love M, et al. International Myositis Assessment and Clinical Studies Group:defining clinical improvement in adult and juvenile myositis. J Rheumatol,2003;30(3):603-617.
    [7]

    Sultan SM, Allen E, Oddis CV, et al.Reliability and validity of the myositis disease activity assessment tool. Arthritis Rheum,2008;58(11):3593-3599.
    [8]

    Page G, Chevrel G, Miossec P. Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis. Arthritis Rheum,2004;50(1):199-208.
    [9]

    Liggett SB, Kelly RJ, Parekh RR, et al. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Hum Mol Genet,2007;16(22):2740-2750.
    [10]

    McGraw DW, Elwing JM, Fogel KM, et al.Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. J Clin Invest,2007;117(5):1391-1398.
    [11]

    Ngai J, Inngjerdingen M, Berge T, et al. Interplay between the heterotrimeric g-protein subunits galphaq and galphai2 sets the threshold for chemotaxis and TCR activation. BMC Immunol,2009;10:27.doi: 10.1186/1471-2172-10-27.
    [12]

    Ngai J, Methi T, Andressen KW, et al. The heterotrimeric g-protein alpha-subunit galphaq regulates tcr-mediated immune responses through an lck-dependent pathway. Eur J Immunol,2008;38(11):3208-3218.
    [13]

    Misra RS, Shi G, Moreno-Garcia ME, et al. Galphaq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med,2010;207(8):1775-1789.
    • 相关文章
    • 施引文献
    • 资源附件(0)
WeChat 点击查看大图
计量
  • 文章访问数:  3117
  • HTML全文浏览量:  106
  • PDF下载量:  24
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-06-25
  • 修回日期:  2013-07-07
  • 发布日期:  2013-09-19

目录

摘要
HTML全文
    参考文献(13)
    相关文章
    施引文献
    资源附件(0)

    /

    返回文章
    返回

    数据库收录

    四川大学学报医学版
    微信订阅号

    四川大学学报医学版
    官网

    四川大学学报医学版
    微信公众号