349例胃肠道间质瘤的预后影响因素分析
Prognostic Analysis of 349 Cases with Gastrointestinal Stromal Tumor
-
摘要: 目的 探讨影响胃肠道间质瘤(GIST)预后的因素。 方法 回顾性分析我院2006年1月至2011年9月收治的349例GIST患者的病例资料,并分析影响其预后的因素。 结果 335例患者行肿瘤完整切除术,14例行姑息切除术。288例(82.5%)获得随访,随访3~72月(中位时间33月),61例复发或转移,其中33例死亡。非条件logistic回归示:肿瘤部位(P=0.003,OR=1.412,95%CI:1.125~1.772)、危险度分级(P=0.011,OR=2.930,95%CI:1.278~6.716)、术后服用伊马替尼(P=0.009,OR=0.291,95%CI:0.115~0.734)是影响GIST患者术后复发或转移的独立因素。2006年至2008年期间128例患者Cox回归示:直径(P=0.034,OR=2.328,95%CI:1.065~5.089)、危险度分级(P=0.015,OR=3.031,95%CI:1.236~7.428)及术后服用伊马替尼(P=0.011,OR=0.259,95%CI:0.091~0.734)是影响术后3年生存率的独立因素。 结论 GIST缺乏特异性临床表现。肿瘤部位、直径、危险度分级均可影响预后。中高危患者术后口服伊马替尼可改善其预后。Abstract: Objective To investigate the prognostic factors of gastrointestinal stromal tumor(GIST). Methods Clinical data of 349 cases of GIST patients in our hospital between January 2006 and September 2011 were analyzed retrospectively and the prognostic factors were evaluated. Results 335 patients underwent R0 resection and 14 with palliative resection. With a follow-up of 288 (82.5%) patients (median:33 months, range 3-72 months), 61 patients with progressed were observed and 33 of them died. Unconditional logistic regression analysis showed that tumor location (P=0.003, OR=1.412, 95%CI:1.125-1.772), risk classification (P=0.011, OR=2.930, 95%CI:1.278-6.716) and use of imatinib treatment (P=0.009, OR=0.291, 95%CI:0.115-0.734) were independent factors for post-operative recurrence or metastasis. Survival analysis of 128 patients between January 2006 and December 2008, Cox regression analysis demonstrated diameter (P=0.034, OR=2.328, 95%CI:1.065-5.089), risk classification (P=0.015, OR=3.031, 95%CI:1.236-7.428) and use of imatinib treatment (P=0.011, OR=0.259, 95%CI:0.091-0.734) were independent prognosis factors. Conclusions No specific clinical manifestation was observed for GIST. Tumor location, diameter, risk classification and imatinib treatment could influence on prognosis. Radical resection combined with imatinib treatment could improve the prognosis.
-
Keywords:
- Gastrointestinal stromal tumor /
- Clinical characteristics /
- Prognosis /
- Imatinib
-
-
[1] 中国CSCO胃肠间质瘤专家委员会.中国胃肠间质瘤诊断治疗专家共识(2011年版). 中华胃肠外科杂志,2012;15(3):301-307. [2] Joensuu H.Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol,2008;39(10):1411-1419.
[3] Kung YT, Liu KW, Chen SP, et al. Gastrointestinal stromal tumor of the rectum: a case report. J Soc Colon Rectal Surgeon (Taiwan),2011;22:45-49.
[4] 季加孚. 小肠间质瘤的诊断与治疗. 临床外科杂志,2008;16(8):509-511. [5] 耿 韶. 胃肠道和腹内胃肠道外间质瘤的当前认识. 临床消化病杂志,2007;19(1):62-63. [6] Emory TS, Sobin LH, Lukes L, et al. Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol,1999;23(1):82-87.
[7] Yin SH, Xie CM, Mo YX, et al. Correlation of multi-slice spiral CT features to clinicopathologic manifestations of gastrointestinal stromal tumor: a report of 49 cases.Chinese J Cancer,2009;28(9):983.
[8] DeMatteo RP, Gold JS, Saran L, et al. Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer,2008;112(3):608-615.
[9] 杜春燕, 师英强, 傅 红等. 胃肠道间质瘤 103 例预后分析. 中国实用外科杂志,2007;27(4):297-299. [10] Chaudhry UI, DeMatteo RP. Management of resectable gastrointestinal stromal tumor. Hematol Oncol Clin N,2009;23(1):79-96.
[11] Gervaz P, Huber O, Morel P. Surgical management of gastrointestinal stromal tumours. Brit J Surg,2009;96(6):567-578.
[12] Casali P, Jost L, Reichardt P, et al. Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol,2008;19(Suppl 2):35-38.
[13] Euanorasetr C. Outcomes and prognostic factors of primary gastric GIST following complete surgical resection: a single surgeon experience. J Med Assoc Thai,2011;94(1):55.
[14] Lasota J, Miettinen M. Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours. Histopathology,2008;53(3):245-266.
[15] Li J, Gong JF, Li J, et al. Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients. World J Gastroenterol,2012;18(7):698-703.
[16] Blanke CD, Demetri GD, von Mehren M, et al. Long-term results from a randomized phase Ⅱ trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol,2008;26(4):620-625.
[17] Sciot R, Debiec-Rychter M, Daugaard S, et al. Distribution and prognostic value of histopathologic data and immunohistochemical markers in gastrointestinal stromal tumours (GISTs): an analysis of the EORTC phase Ⅲ trial of treatment of metastatic GISTs with imatinib mesylate. Eur J Cancer,2008;44(13):1855-1860.
计量
- 文章访问数: 3370
- HTML全文浏览量: 296
- PDF下载量: 61