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刁玉巧, 江莲, 曲凡等. 心肌营养素-1在新生儿缺氧缺血性脑病心肌损伤中的检测价值[J]. 四川大学学报(医学版), 2015, 46(6): 929-930.
引用本文: 刁玉巧, 江莲, 曲凡等. 心肌营养素-1在新生儿缺氧缺血性脑病心肌损伤中的检测价值[J]. 四川大学学报(医学版), 2015, 46(6): 929-930.
Clinical Pathological Analysis of 29 Cases of Borderline Ovarian Tumors with Intraepithelial Carcinoma[J]. Journal of Sichuan University (Medical Sciences), 2015, 46(6): 929-930.
Citation: Clinical Pathological Analysis of 29 Cases of Borderline Ovarian Tumors with Intraepithelial Carcinoma[J]. Journal of Sichuan University (Medical Sciences), 2015, 46(6): 929-930.

心肌营养素-1在新生儿缺氧缺血性脑病心肌损伤中的检测价值

Clinical Pathological Analysis of 29 Cases of Borderline Ovarian Tumors with Intraepithelial Carcinoma

  • 摘要: 目的 观察新生儿缺氧缺血性脑病(HIE)患儿血浆心肌营养素-1(CT-1)水平的变化及其与心功能的关系,探讨检测CT-1的临床价值。 方法 急性期HIE患儿48例为观察组(心肌损伤22例,非心肌损伤26例),20例正常新生儿为对照组。应用双抗体夹心酶标免疫分析法测定血浆CT-1水平。行心脏彩超检查测量心脏Tei指数。结果 ①HIE患儿急性期血浆CT-1水平较对照组升高( P<0.01)。血浆CT-1水平与血清肌酸激酶同工酶(CK-MB)呈正相关(r=0.57, P<0.01)。②HIE患儿血浆CT-1和CK-MB异常率分别为72.92%、47.91%,差异有统计学意义( P<0.01)。③心肌损伤组血浆CT-1水平、心脏Tei指数较非心肌损伤组均升高( P均<0.01)。血浆CT-1水平与心脏Tei指数呈正相关(r=0.63, P<0.01)。结论 血浆CT-1有助于早期诊断HIE心肌损伤,反映其心功能,可作为临床早期干预、指导治疗的参考指标。

     

    Abstract: Objective To explore the therapeutic effects and advantages of dual channel and dual cycle regimen in the treatment of severe ovarian hyperstimulation syndrome (OHSS) with pregnancy. Methods This study enrolled 60 severe OHSS patients who were successfully pregnant with vitro fertilization-embryo transfer (IVF-ET). The patients were divided into conventional single cycle treatment group (Group A) and dual cycle and dual channel treatment group (Group B). Before the treatment and at the 3rd d and 9th d of treatment, all the patients received the measurements of body mass (BM), abdominal circumference (AC), maximum depth of ascites in ultrasonic (D), serum albumin (ALB), Na+ concentration, white blood cell count (WBC), hematocrit (HCT), drink intake (Intake) and urine volume. The hospital days and costs, the times of paracentesis, the amount of albumin used and pregnancy outcomes were compared at discharge day. Results At the 3rd d of treatment, the changes of BM and HCT between the two groups had not significant difference, but AC and WBC were reduced in both groups, and Group B reduced more ( P<0.05). At the 9th d of treatment,both groups had HCT,AC,D and WBC reduced as well as urine volume and Intake increased, Group B showed more changes ( P<0.05). Compared to the levels of ALB before treatment, it was lower at the 3rd d but higher at the 9th d in both group, with more changes found in Group B ( P<0.05). Compared with Group A, Group B had shorter hospital day, less use of album and paracentesis ( P<0.05). All patients in Group B were successful pregnant, one patient in Group A terminated pregnancy because of poor treatment effect. Conclusion Dual-circulation and dual-channel therapeutic regimen could improve hypoproteinemia, low osmotic pressure, low blood volume for OHSS patients.

     

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