Abstract: Objective?To assess the appropriateness of breast cancer screening technologies in Guizhou province. Methods?We conducted a questionnaire survey, physical examinations, and high-frequency color Doppler ultrasound examinations in 20 183 women from 2010 to 2012 in Guizhou province. Biopsy was performed in those with suspected breast cancers. Results?The participants included 12 089 women who received repeated screening and 8 094 women who were given the screening service for the first time. Ten from the former group were identified with breast cancer (82.7/100 thousand), with the majority (80%) at an early stage. Eleven from the latter group were identified with breast cancer (135.9/100 thousand), 36.4% of whom being at an early stage. This resulted in a detection of 104 per 100 thousand breast cancers, with 57.1% at an early stage (0, Ⅰ stage). The age of the women with breast cancer ranged from 35 to 80 years old. The prevalence peaked at 41-60 years of age, with 71.4% (15/21) falling into this age group (P<0.05). Solid and cystic masses were found in 246 participants, with a minimum mass of 0.2 cm×0.3 cm. Of the 228 participants diagnosed with benign masses, 225 (98.7%) were confirmed by biopsy results. The biopsy also confirmed 6 precancerous lesions. Conclusion?Guizhou had a prevalence of breast cancer of 104/100 thousand, which peaked at 41-60 years old. The screening method used in this study is appropriate.