Abstract: Objective To explore the effects of blood glucose levels on liver functions in patients with sepsis treated in intensive care unit (ICU). Methods We performed a retrospective study on 93 patients with sepsis between March 2014 to January 2015. Patients were divided into two groups according to the initial blood glucose levels when admitted to ICU: high glucose group (blood glucose>10 mmol/L) and normal glucose group(blood glucose≤10 mmol/L). Routine blood test results, liver functions and coagulations function were compared between the two groups. Results On the first day of ICU admission, patients in normal glucose group had lower blood platelet count, higher total bilirubin (TB) and direct bilirubin (DB) levels, lower high density lipoprotein cholesterol (HDL-C) level, lower low density lipoprotein cholesterol (LDL-C) level, longer prothrombin time (PT), longer international normalized ratio (INR), longer activated partial thromboplastin time (APTT) and lower antithrombin Ⅲ(AT Ⅲ) level ( P<0.05). However, seven days after ICU admission, there were no significant differences between the two groups ( P>0.05). Conclusion In patients with sepsis, normal blood glucose level might represent severe liver damage.