Abstract: In this article, we focused on a comprehensive analysis of the current application status of natural medicine in the treatment of osteoporosis, explored their efficacy and safety, and discussed directions and ideas for future research. By reviewing the relevant domestic and international literature, we systematically combed through published research on the etiology, pathogenesis, clinical practice, and modern experimental research of natural medicine applied in the treatment of osteoporosis, and conducted a comprehensive analysis and evaluation accordingly. Natural medicine shows clear curative effects and advantages in the treatment of osteoporosis, which deserves further investigation. Some classic bone-specific natural medicines or prescriptions have potential value in bone growth and development, and they cause few side effects. In the future, further research should be conducted to isolate and extract bioactive anti-osteoporosis compounds from classic prescriptions or bone-specific natural medicines in order to develop potential applications of natural medicine in the treatment of osteoporosis.