Abstract: In high-altitude regions, the unique challenges posed by the low-oxygen environment exert significant stress on the physiological functions of the human body. Currently, there is an urgent need to develop a deeper understanding of the pathogenesis, prevention and treatment strategies, as well as effective interventions, of altitude sickness. In this paper, we explored the self-regulatory mechanisms of the human body in such extreme environments, elaborating on the adaptive mechanisms at the molecular level and the process of acclimatization to high altitudes. Furthermore, we summarized the historical background and distinctive advantages of hypoxic preconditioning in the prevention and treatment of altitude diseases. Additionally, we reviewed various adaptation strategies employed by populations in different high-altitude regions, along with the extensive use of Western medication, single-herb traditional Chinese medicine remedies, and compound formulas and composite formulations of traditional Chinese medicine in these regions. Through this paper, we intend to provide a theoretical foundation for the health maintenance of high-altitude populations and to improve survival strategies under extreme environmental conditions. Our goal is also to provide a theoretical reference for improving the physiological adaptability of newcomers to high altitude areas and for deepening our understanding of the mechanisms of human adaptation to high-altitude environments.