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肿瘤微环境中lncRNA的研究进展

金娟,  赵晓晓,  李丽,  付彩云

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文章导航 > 四川大学学报（医学版）  > 2023 >  54(3): 491-496
金娟, 赵晓晓, 李丽, 等. 肿瘤微环境中lncRNA的研究进展[J]. 四川大学学报（医学版）, 2023, 54(3): 491-496. doi: 10.12182/20230560507
引用本文: 金娟, 赵晓晓, 李丽, 等. 肿瘤微环境中lncRNA的研究进展[J]. 四川大学学报（医学版）, 2023, 54(3): 491-496. doi: 10.12182/20230560507
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JIN Juan, ZHAO Xiao-xiao, LI Li, et al. Latest Findings on Long Noncoding RNA in Tumor Microenvironment[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(3): 491-496. doi: 10.12182/20230560507
Citation: JIN Juan, ZHAO Xiao-xiao, LI Li, et al. Latest Findings on Long Noncoding RNA in Tumor Microenvironment[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES), 2023, 54(3): 491-496. doi: 10.12182/20230560507
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肿瘤微环境中lncRNA的研究进展

doi: 10.12182/20230560507

  • 浙江理工大学生命科学与医药学院 浙江省家蚕生物反应器和生物医药重点实验室 （杭州 310018）

基金项目: 浙江省自然科学基金重大项目（No. LD22H310004）、浙江省“尖兵”“领雁”研发攻关计划项目（No. 2022C03005）和浙江省“万人计划”科技创新领军人才（No. 2019R52011）资助
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    作者简介:

    付彩云，教授，博士生（后）导师，浙江理工大学多肽及蛋白药物研究所所长、生命科学与医药学院副院长，全国巾帼建功先进集体领衔人，应邀担任兰州大学兼职教授和中国科学院肿瘤与基础医学研究所附属肿瘤医院双聘教授。获教育部霍英东教育基金会第十五届高等院校青年教师奖 。 主持结题国家自然科学基金 3 项 （面上项目 2 项和青年基金项目 1 项），浙江省自然科学基金重大项目和面上项目各1项。研究工作发表在 Proc Natl Acad Sci USA、J Am Chem Soc、Angew Chem Int Ed、Signal Transduct Target Ther、Brain Behav Immun 等杂志上。在肿瘤靶向治疗药物研发、髓系白血病标志物鉴定领域以第一发明人授权国家发明专利 9 项（应用转化 4 项）

    通讯作者:

    E-mail：fucy03@zstu.edu.cn

Latest Findings on Long Noncoding RNA in Tumor Microenvironment

  • Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China

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    摘要
  • 摘要: 肿瘤微环境包括肿瘤相关的各种细胞和非细胞组分，其在肿瘤发生、生长和转移的过程中起着非常重要的作用。长链非编码RNA（long noncoding RNA, lncRNA）是一类长度超过200 nt的非编码RNA，参与多种生理和病理进程。研究表明，lncRNA在肿瘤与其微环境相互作用中起重要作用，进而影响肿瘤进展。本文将近年来关于肿瘤微环境中lncRNA的研究进展进行了总结，并探讨其在肿瘤早期诊断和治疗中的应用前景，提出开发有效特异性敲除lncRNA的策略和选择合适的体内运载工具特异性靶向目的细胞等方面是未来深入探索的方向。
    Abstract: Tumor microenvironment incorporates various tumor-related cellular and non-cellular components, playing a crucial role in the process of the pathogenesis, growth, and metastasis of tumors. Long noncoding RNA (lncRNA), a kind of noncoding RNA with a length of more than 200 nt, participates in a variety of physiological and pathological processes. Recent studies have shown that lncRNA plays a vital role in the interaction between tumors and the tumor microenvironment, thereby affecting tumor progression. Herein, we reviewed the research progress on the lncRNA in tumor microenvironment, discussed the potential application of lncRNA in early diagnosis and treatment of tumors, and suggested that some issues should be further explored in future research, including developing effective strategies for knocking out specific lncRNA and selecting appropriate in vivo delivery vehicles targeting specific cells.
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  • 收稿日期:  2023-01-18
  • 修回日期:  2023-04-12
  • 网络出版日期:  2023-05-20
  • 刊出日期:  2023-05-20

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