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西藏地区藏族中老年居民OSTA指数与体质量指数对骨质疏松的筛选价值分析

Osteoporosis Screening Values of Osteoporosis Self-Assessment Tool for Asians Index and Body Mass Index in Middle-Aged and Elderly Tibetan Population in Tibet

    摘要
  • 摘要:
      目的  分析亚洲人骨质疏松自我筛查工具（osteoporosis self-assessment tool for Asians, OSTA）和体质量指数（body mass index, BMI）对西藏地区藏族中老年居民骨质疏松的筛选价值。
      方法  收集西藏地区627例藏族中老年人口学及骨密度（bone mineral density, BMD）等信息。将OSTA指数和BMI与BMD进行相关分析，使用受试者工作特征（receiver operating characteristic, ROC）曲线评估效用。
      结果  女性和男性的OSTA指数、BMI均与BMD具有相关性（P<0.05）。性别分组下，OSTA指数筛选骨质疏松的曲线下面积均高于BMI（女性OSTA指数0.886，BMI 0.785；男性OSTA指数0.957，BMI 0.834）；年龄分组下，中年OSTA指数、BMI筛选骨质疏松的曲线下面积均高于准老年、老年（中年OSTA指数0.939，BMI 0.858；准老年OSTA指数0.860，BMI 0.813；老年OSTA指数0.750，BMI 0.650）。男性中年OSTA指数诊断截断值为−2.20时，灵敏度、特异性均为100%；男性中年BMI诊断截断值为17.512 kg/m2时，灵敏度、特异性均为100%。
      结论  OSTA指数、BMI对西藏地区不同的中老年藏族居民人群骨质疏松的筛选效果不同，OSTA指数筛选效果要优于BMI。

     

    Abstract:
      Objective  To analyze the screening value of osteoporosis self-screening tool for Asia (OSTA) and body mass index (BMI) for osteoporosis (OP) in middle-aged and elderly Tibetan population in the Tibetan region.
      Methods  Data on demographic information, bone mineral density (BMD), and other information of 627 middle-aged and elderly people were collected. Analysis of the correlation between OSTA index, BMI and BMD, and receiver operating characteristic (ROC) curve was performed to evaluate the OP screening effects.
      Results  OSTA index and BMI were correlated with BMD in both female and male populations (P<0.05). In both male and female populations, OSTA index screening results for OP yielded higher area under the curve (AUC) than BMI did, with the AUC for female OSTA index being 0.886 and that for female BMI being 0.785, while that for male OSTA index being 0.957 and that for male BMI being 0.834. When comparing the different age groups, the AUC of OSTA index and BMI of the middle-age group was higher than those of the quasi-elderly group and the elderly group, with the AUC of OSTA index and BMI of the middle-age being 0.939 and 0.858, those of the quasi-elderly group being 0.860 and 0.813, and those of the elderly group being 0.750 and 0.650, respectively. When the optimal cut-off value of diagnosis with OSTA index was −2.20, the sensitivity and specificity were both 100%. When the optimal cut-off value for diagnosis with BMI was 17.512 kg/m2, the sensitivity and specificity were both 100%.
      Conclusion  OSTA index and BMI have different OP screening effects in different middle-aged and elderly Tibetan populations, and OSTA index shows better effects for OP screening than BMI does.

     

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