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陕西地区4 622例儿童变态反应性疾病过敏原分析

贾媛媛 吴华杰 罗建峰 吴诚 王行之 张盼盼 荆增辉 丁亚楠 李娜 崔佳欣 李秋红 孙新

贾媛媛, 吴华杰, 罗建峰, 等. 陕西地区4 622例儿童变态反应性疾病过敏原分析[J]. 四川大学学报(医学版), 2021, 52(5): 832-838. doi: 10.12182/20210960508
引用本文: 贾媛媛, 吴华杰, 罗建峰, 等. 陕西地区4 622例儿童变态反应性疾病过敏原分析[J]. 四川大学学报(医学版), 2021, 52(5): 832-838. doi: 10.12182/20210960508
JIA Yuan-yuan, WU Hua-jie, LUO Jian-feng, et al. Allergen Analysis of 4622 Children with Allergic Diseases in Shaanxi Province[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION), 2021, 52(5): 832-838. doi: 10.12182/20210960508
Citation: JIA Yuan-yuan, WU Hua-jie, LUO Jian-feng, et al. Allergen Analysis of 4622 Children with Allergic Diseases in Shaanxi Province[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION), 2021, 52(5): 832-838. doi: 10.12182/20210960508

陕西地区4 622例儿童变态反应性疾病过敏原分析

doi: 10.12182/20210960508
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    E-mail:sunxin6@fmmu.edu.cn

Allergen Analysis of 4622 Children with Allergic Diseases in Shaanxi Province

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  • 摘要:   目的  了解陕西地区变态反应性疾病儿童的过敏原分布情况。  方法  选取2015年3月–2019年2月就诊于西京医院儿科哮喘中心诊断变态反应性疾病的4 622例患儿为研究对象,采用酶联免疫吸附法进行19种常见过敏原血清特异性IgE(allergen-specific immunoglobulin E, sIgE)的检测。根据性别、年龄、地区将其分组,比较过敏原在不同组间的分布特点。  结果  4 622例儿童对19种过敏原的总体阳性率为62.8%,按高低排序依次为牛奶24.2%、霉菌组合18.0%、狗毛皮屑16.7%、户尘螨16.4%、猫毛皮屑11.7%、腰果10.7%、草类组合10.6%、鸡蛋白8.8%、屋尘7.8%、树类组合7.7%、苋5.6%、桑树4.9%、芒果3.6%、牛肉3.2%、蟑螂2.8%、蟹2.1%、虾1.5%、菠萝0.8%、贝0.3%。按性别分析,男性患儿过敏原阳性率比女性患儿高。按年龄分析,大致呈现随年龄增长吸入性过敏原阳性率上升、食入性过敏原阳性率下降的趋势。按地区分析,陕南地区就诊患儿户尘螨阳性率、陕北地区就诊患儿草类组合阳性率、关中地区就诊患儿牛奶、鸡蛋白阳性率高于其他地区。按聚类及相关性分析大致可将19种过敏原分为4类,其中树木组合、桑树与苋之间存在中度相关性;芒果与桑树、苋之间存在中度相关性;虾与蟹之间存在中度相关性,其余大多过敏原之间存在轻度或微弱相关性。  结论  就诊于西京医院儿科哮喘中心的陕西地区4 622例变态反应性疾病儿童中,男性患儿对过敏原敏感性更高。随年龄增长,大致呈现吸入性过敏原阳性率上升、食入性过敏原阳性率下降的趋势。过敏原分布存在地区差异。部分过敏原之间存在相关性,可能与交叉反应有关。
  • 图  1  不同年龄组和地区过敏原分布情况

    Figure  1.  Analysis of the allergens according to the age and geographical region

    *P<0.016 7, the difference was statistically significant; #P<0.016 7, vs. other groups for the same allergen, the difference was statistically significant.

    图  2  吸入性过敏原的雷达图

    Figure  2.  The radar map of the inhaled allergens

    The closer a point is to the periphery (or the center) of the polygon, that allergen-positive children (at the top of each subgraph) are more (or less) likely to have a positive allergen corresponding to that point.

    图  3  食入性过敏原的雷达图

    Figure  3.  The radar map of the ingested allergens

    图  4  过敏原聚类分析及相关性分析

    Figure  4.  The cluster analysis and correlation analysis of the allergens

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出版历程
  • 收稿日期:  2021-06-11
  • 修回日期:  2021-08-11
  • 网络出版日期:  2021-09-24
  • 刊出日期:  2021-09-20

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