欢迎来到《四川大学学报(医学版)》
郑智尧, 金愈茗, 金思怡, 等. 一氧化碳与疼痛调控[J]. 四川大学学报(医学版), 2021, 52(3): 396-401. DOI: 10.12182/20210560102
引用本文: 郑智尧, 金愈茗, 金思怡, 等. 一氧化碳与疼痛调控[J]. 四川大学学报(医学版), 2021, 52(3): 396-401. DOI: 10.12182/20210560102
ZHENG Zhi-yao, JIN Yu-ming, JIN Si-yi, et al. Carbon Monoxide and Pain Regulation: A Review[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(3): 396-401. DOI: 10.12182/20210560102
Citation: ZHENG Zhi-yao, JIN Yu-ming, JIN Si-yi, et al. Carbon Monoxide and Pain Regulation: A Review[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(3): 396-401. DOI: 10.12182/20210560102

一氧化碳与疼痛调控

Carbon Monoxide and Pain Regulation: A Review

  • 摘要: 一氧化碳(carbon monoxide,CO)是一种由哺乳动物体内血红素氧化酶(heme oxygenase,HO)催化血红素降解产生的重要内源性气体信号传导分子。CO参与了生物体内多种生理活动和病理过程,并与器官组织中的细胞保护和稳态维持密切有关。越来越多的研究表明,CO能够通过多种作用机制,在痛觉的发生、发展过程中发挥调节干预作用,但其作用机制尚未完全明确,且给药方式的不可控因素也使其应用受到较大限制。本文旨在梳理CO在疼痛调控中可能的靶点和途径,并对CO临床应用中所面临的挑战和机遇进行讨论,为CO镇痛药物的进一步研发提供线索。

     

    Abstract: Carbon monoxide (CO) is an endogenous gasotransmitter produced by the degradation of heme in the presence of heme oxygenase (HO) in mammals. It has been demonstrated that CO participates in a variety of physiological activities and pathological processes, and is closely related to cell protection and homeostasis maintenance in organ tissues. It has been shown by a growing number of studies that CO may play a regulatory and interventional role in the process of the occurrence and development of pain through a variety of mechanisms of action. However, its mechanism of action is still not fully understood and the uncontrollable factors concerning CO administration also placed considerable limitation to its application. This paper reviews the potential targets and pathways of CO in pain regulation and discusses the challenges and opportunities in the clinical application of CO in order to provide suggestions for further exploration and development of CO analgesics.

     

© 2021 《四川大学学报(医学版)》编辑部 版权所有 cc

开放获取 本文遵循知识共享署名—非商业性使用4.0国际许可协议(CC BY-NC 4.0),允许第三方对本刊发表的论文自由共享(即在任何媒介以任何形式复制、发行原文)、演绎(即修改、转换或以原文为基础进行创作),必须给出适当的署名,提供指向本文许可协议的链接,同时标明是否对原文作了修改;不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问 https://creativecommons.org/licenses/by-nc/4.0

/

返回文章
返回