Volume 52 Issue 1
Jan.  2021
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LI Jin-tao, LEI Ming-zhu, LEI Qun-ying, et al. A Review of Metabolic Stress and Development of Pancreatic Cancer[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION), 2021, 52(1): 5-10. doi: 10.12182/20210160502
Citation: LI Jin-tao, LEI Ming-zhu, LEI Qun-ying, et al. A Review of Metabolic Stress and Development of Pancreatic Cancer[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION), 2021, 52(1): 5-10. doi: 10.12182/20210160502

A Review of Metabolic Stress and Development of Pancreatic Cancer

doi: 10.12182/20210160502
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  • Corresponding author: LEI Qun-ying,E-mail: qlei@fudan.edu.cn; ;YIN Miao,E-mail:miaoyin@fudan.edu.cn
  • Received Date: 2020-11-04
  • Rev Recd Date: 2020-12-22
  • Publish Date: 2021-01-20
  • Pancreatic ductal adenocarcinoma (PDAC) is one of the most notorious malignancies with a 5-year survival rate of less than 8%. Therefore, it is crucial to investigate the molecular mechanism underlining PDAC initiation, promotion, and progression for efficient treatment of PDAC. In order to adapt and survive in an extremely adverse microenvironment of hypoxia and insufficiency of nutrients and energy, PDAC cells undergo extensive metabolic modification triggered by intrinsic signalings which are activated by different genetic events, including mutations occurred at KRAS, TP53, and DPC4/SMAD4, collaboratively promoting PDAC development. Notably, PDCA cells have extensive crosstalk in the form of reciprocal metabolic flux with its surrounding microenvironment to facilitate tumor advancement and therapy resistance. We herein summarize recent findings of PDAC metabolism and discuss metabolic rewiring-based therapeutic strategies.
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