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“两段式”覆膜支架治疗Stanford B型主动脉夹层术后主动脉重塑特点

The Characteristics of Aortic Remodeling after Thoracic Endovascular Aortic Repair using Two-stent Graft Implantation for Stanford Type B Aortic Dissection

  • 摘要:
      目的  探讨应用“两段式”覆膜支架行胸主动脉腔内修复术(thoracic endovascular aortic repair using two-stent graft implantation,TEVAR-TSI)治疗Stanford B 型主动脉夹层术后主动脉重塑特点。
      方法  回顾性收集2013年1月−2019年5月应用TEVAR-TSI治疗Stanford B 型主动脉夹层的128例患者的临床及影像学资料,分析术前(T0)、术后1周(T1)、术后3个月(T2)、术后6个月(T3)及术后1年(T4)时,主动脉近端破口平面(L1)、气管分叉平面(L2)、第一枚支架末端平面(L3)、腹腔干动脉平面(L4)及最低侧肾动脉下缘平面(L5)的真、假腔内径实测值及其变化率,以及假腔血栓化情况。
      结果  支架覆盖的胸主动脉段(L1~L3):在L1~L3平面,术后真腔内径呈增大及假腔内径呈缩小趋势,真腔内径变化与随访时间呈正相关(r=0.721、0.827、0.893,P<0.05),真腔内径变化率与随访时间也呈正相关( r =0.763、0.818、0.902, P<0.05),而假腔内径变化与随访时间呈负相关(r=−0.750、−0.927、−0.934,P<0.05),假腔内径变化率与随访时间亦呈负相关( r =−0.774、−0.935、−0.952,P<0.05)。支架未覆盖的腹主动脉段(L4~L5):在L4平面,真腔内径呈缓慢增大趋势,在术后1年较术前扩大13.7%,差异有统计学意义(P=0.007),而假腔内径变化差异无统计学意义(P=0.406)。在L5平面,真腔及假腔内径均呈缓慢增大的趋势,到术后1年真腔内径较术前扩大10.1%,假腔内径较术前扩大13.6%,差异均有统计学意义(P分别为0.048,0.017)。另外,末次随访CT血管成像(CT angiography,CTA)结果显示:假腔血栓化程度在支架覆盖段亦明显优于未覆盖段。
      结论  Stanford B型主动脉夹层患者行TEVAR-TSI术后,支架覆盖的胸主动脉段假腔血栓吸收率高且主动脉形态重塑更为理想,未能覆盖的腹主动脉段的主动脉重塑效果不理想,且腹主动脉内径趋于增大,应严密随访监测。

     

    Abstract:
      Objective  To investigate the characteristics of aortic remodeling after thoracic endovascular aortic repair using two-stent graft implantation (TEVAR-TSI) for Stanford B aortic dissection.
      Methods  The clinical and imaging data of 128 patients who underwent TEVAR-TSI for Stanford B aortic dissection in the First Affiliated Hospital of Hebei North University from January 2013 through May 2019 were retrospectively collected. CT images were obtained before (T0) TEVAR-TSI and, 1 week (T1), 3 months (T2), 6 months (T3), 1 year (T4) after TEVAR-TSI. The maximum diameter of the true lumen and false lumen in the short axis view was accessed at five levels: L1: the level of primary tear entry, L2: the level of the bronchial bifurcation, L3: the level of the distal of the first stent-graft, L4: the level of the celiac trunk, L5: the level of the lowest renal arteries. The false lumen thrombosis in the thoracic aorta and abdominal aorta were assessed at different times, the false lumen and true lumen changes in diameter were evaluated between the preoperative and postoperative CT scan.
      Results  The stented segment of the descending thoracic aorta was evaluated (L1-L3): The true lumen diameter showed an increasing trend and the false lumen diameter showed an decreasing trend at levels L1, L2, and L3, the change of true lumen diameter was positively correlated with the follow-up time (r=0.721, 0.827, 0.893, P<0.05), and the change rate of true lumen diameter was positively correlated with the follow-up time (r=0.763, 0.818, 0.902, P<0.05), and the change of false lumen diameter was negatively correlated with the follow-up time (r=−0.750, −0.927, −0.934, P<0.05), and the change rate of false lumen diameter was negatively correlated with the follow-up time (−0.774, −0.935, −0.952, P<0.05). When the unstented segment of the abdominal aorta was evaluated (L4-L5), the average true lumen diameter at the level of celiac trunk increased significantly at 1 year by 13.7% (P=0.007), however, the average false lumen diameter did not change over time (P=0.406). The average true lumen diameter and false lumen diameter at the level of the lowest renal arteries increased over time as well, the average true lumen increased by 10.1%, and the average false lumen increased by 13.6% (P=0.048, 0.017). Besides, the complete false lumen thrombosis rate of the stented segment of the descending thoracic aorta was higher than that of the unstented segment of the abdominal aorta.e complete false lumen thrombosis rate of the stented segment of the descending thoracic aorta was higher than that of the unstented segment of the abdominal aorta.
      Conclusion  After receiving TEVAR-TSI, Stanford type B aortic dissection patients had high thrombosis absorption rate in the thoracic aortic segment covered by stent, and the aortic remodeling was more ideal. The aortic remodeling effect in the abdominal aortic segment not covered was not ideal, and the inner diameter of the abdominal aorta tended to increase. Therefore, close follow-up monitoring should be conducted.

     

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