Volume 51 Issue 6
Nov.  2020
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ZHU Rui, LIU Wei-qing, ZHANG Peng, et al. Current Advances in Peri-implantitis Mouse Model[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION), 2020, 51(6): 767-770. doi: 10.12182/20201160205
Citation: ZHU Rui, LIU Wei-qing, ZHANG Peng, et al. Current Advances in Peri-implantitis Mouse Model[J]. JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION), 2020, 51(6): 767-770. doi: 10.12182/20201160205

Current Advances in Peri-implantitis Mouse Model

doi: 10.12182/20201160205
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  • Corresponding author: E-mail: xingliangdent@vip.163.com
  • Received Date: 2020-07-15
  • Rev Recd Date: 2020-10-19
  • Publish Date: 2020-11-20
  • Peri-implantitis is the most common and intractable complication of dental implant-supported prothesis affecting its long-term success, and is one of the main reasons for implant failure. Due to the limitation of the research methods, the pathogenesis and pathological processes of peri-implantitis remain unclear. Animal models are indispensable tools to study the pathogenesis of diseases. With the advances of the dental implants, the peri-implantitis mouse model has been used in experimental research. This paper summarized recent studies from the following five aspects: the advantages of the mouse model, the influence of mouse strain, the design of micro-implant, the way of implant insertion, as well as the induction of peri-implantitis, aiming to provide references and help for researchers. Compared with the large animal models of peri-implantitis, the mouse model of peri-implantitis is more flexible in use. Lower costs can better control the sample number and shorter induction time can better control experimental duration. The completion of mouse genome sequencing and the progress of the genetic operating system also make the pathogenetic study possible. However, the mouse model of peri-implantitis still has some limitations. Limited by the small size of mouse oral cavity, implant insertion surgery is technically demanding, and complex surgeries are even more challenging. Moreover, due to short history of the peri-implantitis mouse model, its corresponding technical theories such as implantation methods, peri-implantitis induction methods and so on are not unified yet and still need further research and development.
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  • [1]
    郭淑娟, 刘倩, 丁一. 牙周病和植体周病国际新分类简介. 国际口腔医学杂志,2019,46(2): 125–134. doi: 10.7518/gjkq.2019001
    DREYER H, GRISCHKE J, TIEDE C, et al. Epidemiology and risk factors of peri-implantitis: a systematic review. J Periodont Res,2018,53(5): 657–681. doi: 10.1111/jre.12562
    DOORNEWAARD R, JACQUET W, COSYN J, et al. How do peri‐implant biologic parameters correspond with implant survival and peri‐implantitis? A critical review. Clin Oral Implants Res, 2018, 29(6):100-123.
    CARCUAC O, BERGLUNDH T. Composition of human peri-implantitis and periodontitis lesions. J Dent Res,2014,93(11): 1083–1088. doi: 10.1177/0022034514551754
    SCHWARZ F, SCULEAN A, ENGEBRETSON S P, et al. Animal models for peri-implant mucositis and peri-implantitis. Periodontology 2000,2015,68(1): 168–181. doi: 10.1111/prd.12064
    WEINBERG M A, BRAL M. Laboratory animal models in periodontology. J Clin Periodontol,1999,26(6): 335–340. doi: 10.1034/j.1600-051X.1999.260601.x
    SCHOU S, HOLMSTRUP P, STOLTZE K, et al. Probing around implants and teeth with healthy or inflamed peri-implant mucosa/gingiva. A histologic comparison in cynomolgus monkeys (Macaca fascicularis). Clin Oral Implant Res,2002,13(2): 113–126. doi: 10.1034/j.1600-0501.2002.130201.x
    PERSSON L G, ERICSSON I, BERGLUNDH T, et al. Guided bone regeneration in the treatment of periimplantitis. Clin Oral Implant Res,1996,7(4): 366–372. doi: 10.1034/j.1600-0501.1996.070410.x
    YU X, HU Y, FREIRE M, et al. Role of toll-like receptor 2 in inflammation and alveolar bone loss in experimental peri-implantitis versus periodontitis. J Periodont Res,2018,53(1): 98–106. doi: 10.1111/jre.12492
    DENG S, HU Y, ZHOU J, et al. TLR4 mediates alveolar bone resorption in experimental peri‐implantitis through regulation of CD45+ cell infiltration, RANKL/OPG ratio, and inflammatory cytokine production. J Periodontol,2020,91(5): 671–682. doi: 10.1002/JPER.18-0748
    宋续军, 张倩, 王少磊, 等. 实验性种植体周围炎小鼠模型的建立及TNF-α在模型小鼠牙龈组织中的表达. 吉林大学学报(医学版),2020,46(1): 40–44.
    林兆宇, 高翔. 小鼠的遗传学研究. 生命科学,2006,18(5): 437–441. doi: 10.3969/j.issn.1004-0374.2006.05.007
    黄镜静, 谭颖徽. 牙周炎动物模型的研究进展. 现代生物医学进展,2012,12(5): 992–994.
    HIYARI S, NAGHIBI A, WONG R, et al. Susceptibility of different mouse strains to peri-implantitis. J Periodont Res,2018,53(1): 107–116. doi: 10.1111/jre.12493
    DING L, ZHANG P, WANG X, et al. A doxycycline-treated hydroxyapatite implant surface attenuates the progression of peri-implantitis: a radiographic and histological study in mice. Clin Implant Dent Relat Res,2019,21(1): 154–159. doi: 10.1111/cid.12695
    VARON-SHAHAR E, SHUSTERMAN A, PIATTELLI A, et al. Peri-implant alveolar bone resorption in an innovative peri-implantitis murine model: effect of implant surface and onset of infection. Clin Implant Dent Relat Res,2019,21(4): 723–733. doi: 10.1111/cid.12800
    WONG R L, HIYARI S, YAGHSEZIAN A, et al. Comparing the healing potential of late-stage periodontitis and peri-implantitis. J Oral Implantol,2017,43(6): 437–445. doi: 10.1563/aaid-joi-D-17-00157
    NGUYEN VO T N, HAO J, CHOU J, et al. Ligature induced peri-implantitis: tissue destruction and inflammatory progression in a murine model. Clin Oral Implant Res,2017,28(2): 129–136. doi: 10.1111/clr.12770
    PIRIH F Q, HIYARI S, BARROSO A D V, et al. Ligature-induced peri-implantitis in mice. J Periodont Res,2015,50(4): 519–524. doi: 10.1111/jre.12234
    刘秀娟, 丁继芬. 上颌前牙延期种植、即刻种植、早期种植的最新研究进展. 山东医学高等专科学校学报,2016,38(2): 138–140. doi: 10.3969/j.issn.1674-0947.2016.02.022
    MOURARET S, HUNTER D J, BARDET C, et al. A pre-clinical murine model of oral implant osseointegration. Bone,2014,58: 177–184. doi: 10.1016/j.bone.2013.07.021
    BIGUETTI C C, CAVALLA F, SILVEIRA E M, et al. Oral implant osseointegration model in C57Bl/6 mice: microtomographic, histological, histomorphometric and molecular characterization. J Appl Oral Sci, 2018, 26: e20170601[2020-07-03]. https://doi.org/10.1590/1678-7757-2017-0601.
    PAN K, HU Y, WANG Y, et al. RANKL blockade alleviates peri-implant bone loss and is enhanced by anti-inflammatory microRNA-146a through TLR2/4 signaling. Int J Implant Dent,2020,6(1): 15[2020-07-03]. https://doi.org/10.1186/s40729-020-00210-0. doi: 10.1186/s40729-020-00210-0
    LI H, CHEN Z, ZHONG X, et al. Mangiferin alleviates experimental peri-implantitis via suppressing interleukin-6 production and Toll-like receptor 2 signaling pathway. J Orthopaedic Surg Res,2019,14(1): 325[2020-07-03]. https://doi.org/10.1186/s13018-019-1387-3 . doi: 10.1186/s13018-019-1387-3
    HIYARI S, WONG R L, YAGHSEZIAN A, et al. Ligature-induced peri-implantitis and periodontitis in mice. J Clin Periodontol,2018,45(1): 89–99. doi: 10.1111/jcpe.12817
    WONG R L, HIYARI S, YAGHSEZIAN A, et al. Early intervention of peri-implantitis and periodontitis using a mouse model. J Periodontol,2018,89(6): 669–679. doi: 10.1002/JPER.17-0541
    程磊, 于海洋, 吴尧, 等. 牙种植体周围微生物研究. 华西口腔医学杂志,2019,37(1): 7–12.
    TZACH-NAHMAN R, MIZRAJI G, SHAPIRA L, et al. Oral infection with P. gingivalis induces peri-implantitis in a murine model: evaluation of bone loss and the local inflammatory response. J Clin Periodontol,2017,44(7): 739–748. doi: 10.1111/jcpe.12735
    PIRIH F Q, HIYARI S, LEUNG H Y, et al. A murine model of lipopolysaccharide-induced peri-implant mucositis and peri-implantitis. J Oral Implantol, 2015, 41(5): e158–e164.[2020-06-14]. https://doi.org/10.1563/aaid-joi-D-14-00068.
    邹德荣, 朱红, 瞿晓辉. 种植体周围炎动物模型建立及意义. 实用口腔医学杂志,2005,21(4): 463–466. doi: 10.3969/j.issn.1001-3733.2005.04.007
    朱白雪, 高晓蔚, 戴晓玮. 种植体周围炎动物模型的研究进展. 口腔医学,2018,38(8): 747–751.
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