The Association Between Serum Uric Acid and Creatinine in Patients with Hypothyroidism

Objective To determine the relationship between serum uric acid (SUA) and creatinine (SCr) in patients with hypothyroidism. Methods A total of 2 078 people who took physical examinations in the West China Hospital ,Sichuan University in May 2014 participated in this study. Serum thyrotropin (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were detected by electrochemiluminescence. SUA was measured using uricase UV method. The participants were divided into three groups according to their thyroid function: hypothyroidism, subclinical hypothyroidism (SCH) and control. The prevalence of hyperuricemia in each group was estimated. Correlation analyses were performed for the serum indicators. Results There were 1 685 participants in the control group, 38 in the hypothyroidism group, and 355 in the subclinical hypothyroidism group. Hypothyroidism patients had significantly higher levels of TSH than those in the control and SCH groups. Significant differences in serum levels of FT3 and FT4 were found between the three groups. Higher levels of SCr ( P=0.005) and SUA ( P=0.008) were also found in hypothyroidism patients compared with those in the control and SCH groups. In those younger than 60 years, men were more likely to catch hyperuricemia than women, with 50-59 year old men having the highest prevalence of hyperuricemia. Higher prevalence of hyperuricemia in men (compared to women) was also found in those older than 60 years, but without statistical significance ( P=0.09). After correcting for gender, TSH showed no correlations with SUA (r=-0.01, P=0.648) and SCr (r=-0.02, P=0.284); FT4 showed negative correlations with SUA (r=-0.978， P=0.001) and SCr (r=-0.599， P=0.012); FT3 showed negative correlations with SUA (r=-0.745， P=0.007) and SCr (r=-0.457， P=0.034). Conclusion Reduced thyroid hormone levels may lead to elevated SCr levels. And elevated SCr levels may be associated with elevated levels of SUA in patients with hypothyroidism.