Effect of Serum Uric Acid on Renal Function of Patients with Abnormal Glucose Metabolism

Objective To determine the effect of serum uric acid on renal function of patients with abnormal glucose metabolism. Methods A total of 1 495 people who took physical examinations in West China Hospital of Sichuan University in May 2014 were recruited in this study. Serum nitrogen (BUN), creatinine (SCr), triglycerides (TG), cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and uric acid (SUA) of the participants were detected by an automatic biochemical analyzer. The glomerular filtration rate (eGFR) was calculated with CKD-EPI. According to hyperuriceima (HUA), the participants were divided into groups with impaired fasting glucose (IFG), diabetes (DM), IFG with hyperuicimia, and DM with hyperuricemia. The participants with normal fasting plasma glucose served as controls. Renal dysfunction was detected using eGFR≤50 mL/(min·1.73 m2) and SCr≤1.7 μg/mL. Results About 13.18% (197/1 495) participants were identified as IFG with HUA: male (158) /female (39) ratio =4.05; 4.41% (66/1 495) as DM with HUA: male (58) /female (8) ratio =7.25. Participants with HUA in the control, IFG and DM groups had higher levels of CM(155.3mmBUN and SCr and lower levels of eGFR than those without HUA (P<0.05). HUA was more likely to beassociated with serum lipid in the control and IFG groups (most P<0. 05) than in the DM group (P>0.05）. DM patients without HUA had better renal function and serum lipid levels than those who had HUA in their early stage of abnormal glucose metabolism (IFG with HUA) (P<0.05). The prevalence of renal dysfunction of IFG patients with HUA was significantly higher than those without HUA, similar to the prevalence of renal dysfunction of DM patients with HUA (P<0.05). Conclusion Higher percentage of men was found in IFG patients with HUA and DM patients with HUA. HUA is associated with renal dysfunction in patients with abnormal glucose metabolism. HUA intervention should be considered in IFG patients with HUA.