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UCH-L3在上皮性卵巢癌中的表达及临床意义

UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance

    摘要
  • 摘要:
      目的  了解泛素羧基末端水解酶3(UCH-L3)在上皮性卵巢癌(EOC)组织中的表达，分析UCH-L3与EOC患者的临床病理特征及预后的关系。
      方法  通过免疫组化染色方法检测不同卵巢组织中UCH-L3的表达，包括正常卵巢组织20例(正常卵巢组)、上皮性卵巢肿瘤组织26例(良性卵巢肿瘤组)、交界性上皮性卵巢肿瘤组织22例(交界性卵巢肿瘤组)、EOC组织61例(EOC组)，分析UCH-L3的表达与EOC患者临床特征及预后的关系。
      结果  UCH-L3在EOC组卵巢组织中的表达高于良性卵巢肿瘤组和正常卵巢组(P均＜0.05)。UCH-L3在EOC中的FIGO晚期组、分化程度高级别组、有腹腔内转移组中的表达高于FIGO早期组(P=0.006)、分化程度低级别组(P=0.001)和无腹腔内转移组(P=0.032)。UCH-L3在EOC患者肿瘤组织高、低表达组间的生存时间差异无统计学意义。
      结论  UCH-L3在EOC发生发展中可能有一定作用，但与患者的预后无关。

     

    Abstract:
      Objective  To study the expression of ubiquitin C-terminal hydrolase-L3 (UCH-L3) in epithelial ovarian cancer (EOC) tissues, and to analyze the relationship between UCH-L3 expression and the clinic pathological characteristics and prognosis of EOC patients.
      Methods  Immunohistochemical analysis was performed to evaluate UCH-L3 expression in different ovarian epithelial tissue specimens. The correlation between UCH-L3 expression and clinical pathologic parameters, prognosis and of EOC was statistically analyzed.
      Results  The expression level of UCH-L3 in EOC was higher than that in benign ovarian tumor and normal ovary (P < 0.05). The positive expression level of UCH-L3 in late FIGO group, high-level group, group with intraperitoneal metastasis were significantly higher than that in early FIGO group (P=0.006), low-level group (P=0.001), group without intraperitoneal metastasis (P=0.032). There was no significant difference in survival time between the high and low expression groups of UCH-L3.
      Conclusion  UCH-L3 may play a role in EOC pathogenesis and progression.

     

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