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7T心脏磁共振二维组织追踪技术评价树鼩心功能的应用研究

Evaluating Cardiac Function of Tree Shrew (Tupaiabelangeri) using CMR at 7T with 2D Tissue Tracking

    摘要
  • 摘要:
      目的  探讨参照大鼠心功能测量方法，应用7T心脏磁共振二维组织追踪技术(CMR-TT)评价树鼩心功能的潜在价值。
      方法  随机分别选取8只正常成年雄性树鼩及8只正常成年雄性大鼠作为实验对象，两组动物均使用相同成像线圈及磁共振序列分别进行7T磁共振心脏左室短轴位磁共振电影扫描，图像数据由专业心脏图像处理软件进行二维组织追踪分析，分别测量两组动物的射血分数(EF)，左心室收缩峰值径向应力(Err)和周向应力(Ecc)，左心室收缩峰值径向位移(DR)，并计算左心室心肌质量(LVM)以及与体质量(BM)的比值LVM/BM。
      结果  参照大鼠成像方法对树鼩进行心脏磁共振成像，成功率达到100%，图像可清晰显示树鼩心脏各构成要件。树鼩与大鼠之间EF、Err和Ecc、DR差异有统计学意义(P＜0.01)，树鼩的EF、Err和Ecc均明显低于大鼠，并且树鼩的Err，Ecc出现在左室收缩期第15时相，大鼠的Err，Ecc出现在左室收缩期第10时相，树鼩LVM/BM高于大鼠LVM/BM(P＜0.05)。
      结论  采用7T心脏磁共振二维组织追踪技术可以对树鼩心功能进行评价，树鼩与大鼠不同物种之间心功能存在显著差异性。

     

    Abstract:
      Objective  To determine the potential value of the two-dimensional (2D) cardiac magnetic resonance imaging (CMR) tissue tracking (CMR-TT) method in assessing the cardiac function of tree shrew at 7T.
      Methods  Healthy adult tree shrews (male, n=8) and spraguedawley rats(male, n=8) were selected for this study. CMR was performed to acquire the short-axis images of left ventricle at 7T using the same appropriative coil and cine sequence for all experimental animals. The CMR images were processed using the professional cardiac analysis software, calculating ejection fraction (EF), radial peak sysolic strain (Err), circumferential peak sysolic strain (Ecc), radial peak sysolic displacement (DR), and LVM/BM 〔the ratio of left ventricular mass (LVM) to body mass (BM)〕.
      Results  Cine imaging for the tree shrews was 100% successful following the CMR protocol for the rats, with clearly visible main segments of cardiac. Significant differences in EF, Err, Ecc and DR were found between the two groups of animals (P < 0.01). The tree shrews has lower EF, Err and Ecc than the rats. Err and Ecc appeared in the fifteenth phase in left ventriclar systole in the tree shrews, compared with the tenth phase in the rats.The tree shrews also had higher LVM/BM than the rats.
      Conclusion  The cardiac function of tree shrew can be assessed using the 2D CMR-TT method despite significant differences across species.

     

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