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成都市学龄期儿童体重状态转换规律及影响因素的纵向研究

Longitudinal Study of Weight Status Transition Patterns and Associated Factors Among School-Aged Children in Chengdu

  • 摘要:
    目的 探讨成都市6~12岁学龄期儿童正常体重、超重和肥胖状态间的动态转换规律,估计不同体重状态的平均逗留时间和转换概率,并分析性别、基线体重指数(BMI)、年身高增量(AHI)和年体重增量(AWI)对体重状态转换的影响。
    方法 基于成都市中小学生健康体检数据,纳入2021—2025年至少体检过3次的2510名6~12岁学龄期儿童,共计9543人次体检记录。参照《学龄儿童青少年超重与肥胖筛查》(WS/T 586—2018)标准判定体重状态,以实际年龄为时间尺度,构建三状态齐性马尔可夫模型,估计状态间转换强度、1年和5年转换概率及总停留时间。分别纳入性别、基线BMI、AHI、AWI、基线年龄作为协变量,采用似然比检验进行单因素和多因素分析。
    结果 2510名研究对象中,男孩1370名(54.58%),女孩1140名(45.42%),基线平均年龄(7.60±1.98)岁,正常体重者1840名(73.31%),超重者357名(14.22%),肥胖者313名(12.47%)。零模型显示,超重状态的平均逗留时间最短(1.41年,95%置信区间(CI):1.29~1.55),其次是肥胖状态(3.42年,95%CI:2.94~3.98),正常体重状态的平均逗留时间最长(9.70年,95%CI:8.69~10.83)。超重儿童1年内转为正常、肥胖状态的概率分别为30.487%、16.649%;肥胖儿童1年内维持肥胖的概率为77.216%。亚组分析显示女孩超重和肥胖的总停留时间和平均逗留时间较男孩更短,正常体重的平均逗留时间长于男孩(11.80年 vs. 8.34年);基线年龄越小,正常和超重状态维持概率越小,平均逗留时间越短。多因素分析表明,基线BMI每增加1 kg/m2,正常体重向超重状态转换的瞬时转移强度增加77%(风险比(HR)=1.77,95%CI:1.56~2.02),而肥胖儿童逆转为超重的瞬时转移强度降低27%(HR=0.73,95%CI:0.66~0.80),上年度体重AWI每增加1 kg/年,正常→超重瞬时转移强度增加14%(HR=1.14,95%CI:1.05~1.24)。
    结论 成都市学龄期儿童超重状态极不稳定,肥胖状态较稳定,超重是体重干预的关键窗口期。干预重点应放在超重儿童及学龄早期的儿童,尤其应关注基础体重较大的儿童和男生群体。

     

    Abstract:
    Objective  Investigate the dynamic transition patterns among normal weight, overweight, and obesity in school-aged children aged 6-12 years in Chengdu, estimate the mean sojourn time and transition probabilities for different weight statuses; and analyze the effects of sex, baseline body mass index (BMI), annual height increment (AHI), and annual weight increment (AWI) on status transitions.
    Methods Based on health examination data form primary and secondary school students in Chengdu, a total of 2510 school-aged children aged 6-12 years with at least three follow-up visits were enrolled, yielding 9543 person-time records. Weight status was classified according to the Screening for Overweight and Obesity among School-Age Children and Adolescents (WS/T 586—2018) criteria. A three-state homogeneous Markov model was constructed using chronological age as the time scale to estimate transition intensities, 1-year and 5-year transition probabilities, and mean sojourn times. Sex, baseline BMI, AHI, AWI, and baseline age were respectively included as covariates for univariate and multivariable analyses using the likelihood ratio test.
    Results Among the 2510 participants, there were 1370 boys (54.58%) and 1140 girls (45.42%), with a mean baseline age of (7.60 ± 1.98) years. The baseline prevalence of normal weight, overweight, and obesity was 73.31% (n = 1840), 14.22% (n = 357), and 12.47% (n = 313), respectively. The null model showed that the mean sojourn time for overweight was the shortest (1.41 years 95% CI: 1.29-1.55), followed by obesity (3.42 years 95%CI: 2.94-3.98), while normal weight had the longest mean sojourn time (9.70 years 95% CI: 8.69-10.83). Within 1 year, 30.487% of overweight children reverted to normal weight, whereas 16.649% progressed to obesity; 77.216% of obese children remained obese. Subgroup analyses showed that both 1-year and 5-year follow-up results indicated shorter sojourn and mean sojourn times for overweight and obesity in girls compared with boys, while the mean sojourn time for normal weight was longer in girls (11.80 years) than in boys (8.34 years). Children with younger baseline age had lower probabilities of maintaining normal weight and overweight status, as well as shorter mean sojourn times. Multivariable analysis revealed that each 1 kg/m2 increase in baseline BMI was associated with a 77% increase in the instantaneous transition intensity from normal weight to overweight (hazard ratio HR = 1.77, 95% CI: 1.56-2.02, P < 0.001), whereas it reduced the intensity of reversion from obesity to overweight by 27% (HR = 0.73, 95% CI: 0.66-0.80, P < 0.001). Additionally, each 1 kg/year increase in the time-varying AWI from the preceding year was associated with a 14% increase in the instantaneous transition intensity from normal weight to overweight (HR = 1.14, 95% CI: 1.05-1.24, P = 0.002).
    Conclusion Overweight status is highly unstable, whereas obesity is relatively stable among school-aged children in Chengdu. Overweight represents a critical window for weight intervention. Priority for intervention should be given to overweight children and those in early school age, especially boys and children with higher baseline body weight.

     

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