Abstract: With the evolution and development of the concepts of medicine, research concerning precision medicine and precision nursing is constantly expanding and deepening, creating new challenges and opportunities for the nursing practice of enhanced recovery after surgery (ERAS). In this paper, we reviewed the current status of research on precision nursing for ERAS, giving an overview of the application status of precision nursing in ERAS from the perspectives of precision nursing assessment, precision symptom management, precision nutrition support, and precision health education and nursing follow-up. In addition, we analyzed the challenges and their solutions for further promotion and application of precision nursing in ERAS, including strengthening the basic professional knowledge and skills, building a nursing information platform, and actively applying new tools and technologies. In the future, clinical nursing staffs should further utilize the relevant concepts and methods of precision nursing to optimize and improve perioperative patient care strategies, ensure patient safety, enhance the quality of nursing care, improve patient outcomes, and promote a more important role played by precision nursing in ERAS.