An Experimental Study on Inhibition Effects of KH902 on Rat Corneal Neovascularization

Objective To observe the inhibition effect of subconjunctival injection of KH902 on rat corneal neovascularization (CNV)induced by alkaline burn. Methods Alkaline burn was adopted to make rat corneal neovascularization models. The rats were randomly divided into four groups:① Experimental group, subconjunctival injection of KH902 (30 mg/mL); ② Masculine comparison group, subconjunctival injection of dexamethasone (1 mg/mL); ③ Comparison group Ⅰ, subconjunctival injection of solvent of KH902; ④ Comparison group Ⅱ, subconjunctival injection of saline. At the 28^th day after the treatments, the maximal length, area of corneal neovascularization, and the average optical density value of vascular endothelial cell growth factor (VEGF) immunohistochemical staining in the four groups were measured. Results On the 28^th day after molding, the corneal neovascularization area of KH902 experimental group was distinctly smaller than that of dexamethasone group, solvent group and saline group (P<0.05 or P<0.01). The expression of VEGF in the experimental group was distinctly lower than that of other groups (P<0.01). Conclusion Subconjunctival injection of KH902 (30 mg/mL) may inhibit rat corneal neovascularization.