Abstract: Objecitve To explore the effect of bromocriptine in the treatment of male patients with prolactinoma and its impacts on their sexual function. Methods The clinical data of 29 male patients with prolactinomas treated with Bromocriptine were analysed, International Index of Erectile Function-5 (IIEF-5) was used to assess the sexual function of married patients before and after the treatment of Bromocriptine. Results The main clinical symptoms of male patients with prolactinomas were sexual dysfunction, headache and hypopsia, which were released significantly at 6 months after Bromocriptine therapy, with the decrease of serum prolactin (PRL) level (P<0.05)and the improvement of basal testosterone (T) level (P<0.05). The total normalization rate of PRL was 82.8%, and total effective rate of Bromocriptine therapy was 100%. According to the assessment of IIEF-5, all the male patients had their sexual function improved in various degree. Conclusion Bromocriptine can improve the clinical symptoms of male patients with prolactinoma and their sexual function.