Abstract: Objective?To investigate the association between rs3807213 gene polymorphism in interferon-related developmental regulator 1 gene（IFRD1） and the risk of gastric cancer among Chinese. Methods?There were 53 gastric cancer patients and 50 healthy people included in this case-control study. The blood samples were collected from each observed object and genotype (AA，AC，CC) of IFRD1 rs3807213 SNP was detected after polymerase chain reaction (PCR). The relationships of rs3807213 gene polymorphism with gastric cancer risk, clinic and pathologic features were analyzed. Results?Patients with stomach cancer had a significantly higher frequency of rs3807213 C allele distributions （OR=3.759，95%CI=1.521-9.294；P=0.003） than the controls. Compared with control group, patients with gastric cancer had a significantly higher frequency of rs3807213 CC genotype（OR=4.028，95%CI=1.513-10.720；P=0.004）. When stratified by pathological stage of gastric cancer, there was no significant difference observed. Conclusion?IFRD1-rs3807213 polymorphism may be associated with the increased risk of gastric cancer.