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杜信眉, 谢静, 邹玲. 颌骨修复重建的分子调控机制研究进展[J]. 四川大学学报(医学版), 2024, 55(1): 224-229. DOI: 10.12182/20240160101
引用本文: 杜信眉, 谢静, 邹玲. 颌骨修复重建的分子调控机制研究进展[J]. 四川大学学报(医学版), 2024, 55(1): 224-229. DOI: 10.12182/20240160101
DU Xinmei, XIE Jing, ZOU Ling. Advances in Molecular Regulatory Mechanisms of Jaw Repair and Reconstruction[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(1): 224-229. DOI: 10.12182/20240160101
Citation: DU Xinmei, XIE Jing, ZOU Ling. Advances in Molecular Regulatory Mechanisms of Jaw Repair and Reconstruction[J]. Journal of Sichuan University (Medical Sciences), 2024, 55(1): 224-229. DOI: 10.12182/20240160101

颌骨修复重建的分子调控机制研究进展

Advances in Molecular Regulatory Mechanisms of Jaw Repair and Reconstruction

  • 摘要: 临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以及骨重塑等阶段。骨形态发生蛋白(bone morphogenetic proteins, BMPs)、转化生长因子-β(transforming growth factor beta, TGF-β)、血管内皮生长因子(vascular endothelial-derived growth factor, VEGF)等生长因子在促进颌骨骨再生中发挥着重要的作用。细胞因子如白细胞介素和肿瘤坏死因子在调节炎症反应和骨修复中具有双重作用。近年来,分子生物学研究在颌骨修复重建领域中已经取得了显著进展。组织工程技术在颌骨修复中有着重要的应用,包括干细胞疗法、生物活性支架和生长因子递送系统。但这些治疗手段所涉及的复杂的颌骨修复重建分子调控机制尚不清晰,有待进一步研究。未来的研究方向将集中在精确控制这些分子过程,以及开发更高效的组合治疗策略,以促进颌骨的有效和功能性重建。本综述旨在探讨颌骨修复重建的分子调控机制及其治疗策略的最新进展,为颌骨修复重建的机制提供分子层面的理解。

     

    Abstract: Jawbone injuries resulting from trauma, diseases, and surgical resections are commonly seen in clinical practice, necessitating precise and effective strategies for repair and reconstruction to restore both function and aesthetics. The precise and effective repair and the reconstruction of jawbone injuries pose a significant challenge in the field of oral and maxillofacial surgery, owing to the unique biomechanical characteristics and physiological functions of the jawbone. The natural repair process following jawbone injuries involves stages such as hematoma formation, inflammatory response, ossification, and bone remodeling. Bone morphogenetic proteins (BMPs), transforming growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), and other growth factors play crucial roles in promoting jawbone regeneration. Cytokines such as interleukins and tumor necrosis factor play dual roles in regulating inflammatory response and bone repair. In recent years, significant progress in molecular biology research has been made in the field of jawbone repair and reconstruction. Tissue engineering technologies, including stem cell therapy, bioactive scaffolds, and growth factor delivery systems, have found important applications in jawbone repair. However, the intricate molecular regulatory mechanisms involved in the complex jawbone repair and reconstruction methods are not fully understood and still require further research. Future research directions will be focused on the precise control of these molecular processes and the development of more efficient combination therapeutic strategies to promote the effective and functional reconstruction of the jawbone. This review aims to examine the latest findings on the molecular regulatory mechanisms of the repair and reconstruction of jawbone injuries and the therapeutic strategies. The conclusions drawn in this article provide a molecular-level understanding of the repair of jawbone injuries and highlight potential directions for future research.

     

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