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凌莉琴, 廖娟, 张崇唯等. 丹七胶囊对健康人血小板黏附、活化、聚集功能的影响[J]. 四川大学学报(医学版), 2017, 48(1): 124-126.
引用本文: 凌莉琴, 廖娟, 张崇唯等. 丹七胶囊对健康人血小板黏附、活化、聚集功能的影响[J]. 四川大学学报(医学版), 2017, 48(1): 124-126.

丹七胶囊对健康人血小板黏附、活化、聚集功能的影响

  • 摘要: 目的 探讨中药丹七胶囊对健康人血小板功能的影响,为该中药的进一步开发和利用提供依据。方法 16名健康志愿者随机均分为低剂量和高剂量(4粒/次和6粒/次,3次/日)两组,连续口服丹七胶囊2周,于服药前1周、服药后1周、2周三个时间点采集空腹静脉血,检测血常规、凝血常规、肝肾功指标、血浆游离P-选择素和血管性假血友病因子(von Willebrand factor,vWF)以及血小板最大聚集率 (maximum aggregation, MA)。结果 服用丹七胶囊后,两个剂量组的血常规、凝血常规、肝肾功指标和血浆vWF水平,与服药前相比差异均无统计学意义( P>0.05),而两个剂量组的血浆游离P-选择素和血小板MA出现下降,与服药前相比,差异均有统计学意义( P<0.05);服药2周与服药1周相比,血浆游离P-选择素和血小板MA差异均无统计学意义( P>0.05)。结论 口服丹七胶囊可抑制血小板活化,降低血小板聚集功能,对正常受试者凝血、肝肾功能和vWF水平无明显影响。

     

    Abstract: Objective To study the effects of Danqi Capsule on platelet function in healthy people. Methods Sixteen healthy volunteer were divided into low dose (4 capsules/time, 3 times/d) and high dose group (6 capsules/time, 3 times/d), and received Danqi Capsule by orally administration for 2 weeks. The venous blood were collect at 3 time points: one week before taking Danqi Capsule (control), one week after taking Danqi Capsule (1 week), two week after taking Danqi Capsule (2 weeks). Blood samples were used for the measurements of conventional coagulation examination, complete blood count, liver and kidney function test, platelet aggregation test, the plasma levels of P-selectin and von Willebrand factor (vWF), and maximum aggregation (MA). Results In both dosage group, Danqi capsule(1 week/2 weeks) administration showed no difference in conventional coagulation examination, complete blood count, liver and kidney function test, or the plasma level of vWF ( P>0.05), but showed difference (decreased) in platelet aggregation test and the plasma level of P-selectin (vs. control, P<0.05). Conclusion Danqi Capsule inhibits platelet activation and platelet aggregation, but not affects the plasma level of vWF, the coagulation function or the hepatorenal function in normal subjects.

     

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