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周景峰, 周琴, 陈纯, 等. 内质网应激与肿瘤转移[J]. 四川大学学报(医学版), 2021, 52(1): 11-15. DOI: 10.12182/20210160503
引用本文: 周景峰, 周琴, 陈纯, 等. 内质网应激与肿瘤转移[J]. 四川大学学报(医学版), 2021, 52(1): 11-15. DOI: 10.12182/20210160503
ZHOU Jing-feng, ZHOU Qin, CHEN Chun, et al. A Review of the Roles of Endoplasmic Reticulum Stress in Cancer Cell Metastasis[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(1): 11-15. DOI: 10.12182/20210160503
Citation: ZHOU Jing-feng, ZHOU Qin, CHEN Chun, et al. A Review of the Roles of Endoplasmic Reticulum Stress in Cancer Cell Metastasis[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(1): 11-15. DOI: 10.12182/20210160503

内质网应激与肿瘤转移

A Review of the Roles of Endoplasmic Reticulum Stress in Cancer Cell Metastasis

  • 摘要: 肿瘤转移是一个多步骤、低效率的生物学过程,在这个复杂过程中,肿瘤细胞发生遗传学及表观遗传学改变,使肿瘤细胞适应转移过程中所面临的不利微环境,最终在远处器官形成转移灶。内质网应激(endoplasmic reticulum stress,ER stress)引起的未折叠蛋白反应(unfolded protein response,UPR)是调节细胞适应不利微环境的最为重要的信号通路之一,在肿瘤细胞生长、存活、分化和维持蛋白质稳态等过程中发挥着至关重要的作用,参与到肿瘤转移的各个阶段。本文对内质网应激信号分子促进肿瘤细胞发生上皮间充质转化(epithelial–mesenchymal transition,EMT)、促进肿瘤的存活、促进肿瘤的免疫逃逸、促进肿瘤血管新生、促进肿瘤细胞黏附以及促进肿瘤细胞从休眠中苏醒等转移相关特性及其机制进行综述,为开发治疗肿瘤转移的新靶标提供参考。

     

    Abstract: Metastasis is a multistep and low-efficiency biological process driven by acquisition of genetic and/or epigenetic alterations within tumor cells. These evolutionary alterations enable tumor cells to thrive in the inhospitable microenvironment they encounter in the process of metastasis and eventually lead to macroscopic metastases in distant organs. The unfolded protein response (UPR) induced by endoplasmic reticulum (ER) stress is one of the most important mechanisms regulating cellular adaptation to an adverse microenvironment. UPR is involved in all stages of metastasis, playing an important role in tumor cell growth, survival, and differentiation and the process of maintaining protein hemostasis. Sustained activation of ER stress sensors endows tumor cells with better epithelial–mesenchymal transition (EMT), survival, immune escape, angiogenesis, cellular adhesion, dormancy-to reactivation capacity in the process of metastasis. Here, we discussed the role of UPR in regulating the above-mentioned abilities of tumor cells during metastasis, providing a reference for development of new targets for the treatment of tumor metastasis.UPR in regulating the above-mentioned characteristics and mechanisms of tumor cells during metastasis, providing a reference for development of new targets for the treatment of tumor metastasis.

     

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