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赵昆, 时荣臣, 缪洪明. 肿瘤相关巨噬细胞的脂质代谢重编程[J]. 四川大学学报(医学版), 2021, 52(1): 45-49. DOI: 10.12182/20210160202
引用本文: 赵昆, 时荣臣, 缪洪明. 肿瘤相关巨噬细胞的脂质代谢重编程[J]. 四川大学学报(医学版), 2021, 52(1): 45-49. DOI: 10.12182/20210160202
ZHAO Kun, SHI Rong-chen, MIAO Hong-ming. A Review of the Lipid Metabolism Reprogramming in Tumor Associated Macrophages[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(1): 45-49. DOI: 10.12182/20210160202
Citation: ZHAO Kun, SHI Rong-chen, MIAO Hong-ming. A Review of the Lipid Metabolism Reprogramming in Tumor Associated Macrophages[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(1): 45-49. DOI: 10.12182/20210160202

肿瘤相关巨噬细胞的脂质代谢重编程

A Review of the Lipid Metabolism Reprogramming in Tumor Associated Macrophages

  • 摘要: 肿瘤相关巨噬细胞(tumor associated macrophages,TAMs)是实质肿瘤中最常见的间质细胞类型之一,且与肿瘤微环境的免疫抑制状态有着紧密联系,并促进肿瘤的恶性进展。TAMs内的代谢发生了重编程,并且参与调控其自身的极化以及相应的功能表型。本文详细论述了TAMs中包括三酰甘油、脂肪酸及其衍生物、胆固醇和磷脂在内的脂质代谢重编程以及它们对肿瘤进展的调控。然而,肿瘤细胞与肿瘤微环境间质细胞的代谢极具异质性。肿瘤细胞与间质细胞之间脂代谢重编程的异同点以及重编程如何调控细胞活性的机制值得深入探索。同时,综合考虑肿瘤不同的组织类型、不同的发展阶段,精准靶向干预TAMs脂质代谢重编程,促进TAMs向M1样巨噬细胞极化,将成为代谢调节肿瘤免疫治疗的新策略。

     

    Abstract: Tumor associated macrophages (TAMs) are one of the most common types of stromal cells in solid tumors. They are closely related to the immunosuppressive status of tumor microenvironment and potentiate the malignant progress of tumors. Studies have shown that metabolism in tumor associated macrophages has been reprogrammed and involved in the regulation of their own polarization and corresponding functions and phenotypes. Metabolic reprogramming refers to the alteration of key enzymes activity, substrate and its associated metabolites’ concentration in a certain metabolic pathway, which accounts for the disorder of original metabolic states. In this paper, we mainly concentrated on the lipid metabolic reprogramming of TAMs, including triglycerides, fatty acids and their derivatives, cholesterol, phospholipids, and their regulations on tumor progression. However, the metabolism of tumor and tumor microenvironment cells is highly heterogeneous. It is worthy of further exploration on the similarities and differences of lipid metabolism reprogramming between stromal cells and tumor cells, and the mechanism of how reprogramming modulates cell activity. It will be a new strategy for immunotherapy of tumor with metabolic intervention to accurately target the lipid metabolism reprogramming of TAMs, so as to promote the polarization of TAMs to M1 like macrophages, when synthetically considering the diverse types of tumors and different stages of development.

     

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