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任文静, 唐勇. 嘌呤信号与心理应激研究进展[J]. 四川大学学报(医学版), 2021, 52(1): 33-38. DOI: 10.12182/20210160102
引用本文: 任文静, 唐勇. 嘌呤信号与心理应激研究进展[J]. 四川大学学报(医学版), 2021, 52(1): 33-38. DOI: 10.12182/20210160102
REN Wen-Jing, TANG Yong. A Review of the State of Purinergic Signaling and Psychological Stress[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(1): 33-38. DOI: 10.12182/20210160102
Citation: REN Wen-Jing, TANG Yong. A Review of the State of Purinergic Signaling and Psychological Stress[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(1): 33-38. DOI: 10.12182/20210160102

嘌呤信号与心理应激研究进展

A Review of the State of Purinergic Signaling and Psychological Stress

  • 摘要: 嘌呤信号广泛参与机体的生理病理过程,而心理应激作为机体应对应激源时表现出的一种体内不协调的状态,与嘌呤信号关系密切。应激导致的ATP异常释放,进一步导致与ATP相关受体水平异常,从而出现心理应激相关疾病,如焦虑、抑郁、创伤后应激障碍、精神分裂症等。现针对嘌呤信号参与心理应激的研究多集中于ATP、腺苷以及P2X2、P2X3、P2X4、P2X7、A1、A2A受体,但其具体机制还有待进一步研究;并且目前针对ATP实时监测技术应用于应激模型动物的研究尚少,ATP在应激发生过程中的具体生物学作用还未可知。因此本文重点就心理应激与嘌呤信号之间的关系进行综述,探讨心理应激状态下,嘌呤信号的表达变化,以及嘌呤信号的表达是否会反过来介导应激反应,提出现有ATP实时监测技术以及嘌呤能化合物用于心理应激领域研究的假设,为今后从嘌呤信号途径解析心理应激的形成机制或治疗靶点提供新的思路。

     

    Abstract: Purinergic signaling is involved in multiple physiological and pathological processes. Psychological stress, as an inharmonious state in response to stressors, is closely related to the function or dysfunction of purinergic signaling. Abnormal expression of ATP interceptors caused by stress leads to psychological stress-related diseases, such as anxiety, depression, post-traumatic stress disorder and schizophrenia. Recent studies demonstrate that a complex network of purinergic signaling (such as ATP, adenosine and P2X2R, P2X3R, P2X4R, P2X7R, A1R, A2AR) plays a key role in psychological stress, but the specific mechanism remains to be further studied. And few studies focus on the application of ATP real-time detecting to psychological stress animal models, so the specific biological role of ATP in the process of stress is still unknown. This review will summarize the relationship between purinergic signaling and psychological stress and propose to apply the duplicate ATP real-time detection technology and purinergic compounds on psychological stress research in order to provide novel potential targets for the treatment of stress-related diseases.

     

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