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陈秒, 李娅姣, 钱宏, 等. 声学微泡造影技术测定动物模型中肺血量的可行性及可重复性研究[J]. 四川大学学报（医学版）, 2020, 51(6): 839-846. DOI: 10.12182/20201160106
引用本文: 陈秒, 李娅姣, 钱宏, 等. 声学微泡造影技术测定动物模型中肺血量的可行性及可重复性研究[J]. 四川大学学报（医学版）, 2020, 51(6): 839-846. DOI: 10.12182/20201160106
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CHEN Miao, LI Ya-jiao, QIAN Hong, et al. The Feasibility and Repeatability of Ultrasound Microbubble Angiography in the Determination of Pulmonary Blood Volume in Animal Models[J]. Journal of Sichuan University (Medical Sciences), 2020, 51(6): 839-846. DOI: 10.12182/20201160106
Citation: CHEN Miao, LI Ya-jiao, QIAN Hong, et al. The Feasibility and Repeatability of Ultrasound Microbubble Angiography in the Determination of Pulmonary Blood Volume in Animal Models[J]. Journal of Sichuan University (Medical Sciences), 2020, 51(6): 839-846. DOI: 10.12182/20201160106
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声学微泡造影技术测定动物模型中肺血量的可行性及可重复性研究

The Feasibility and Repeatability of Ultrasound Microbubble Angiography in the Determination of Pulmonary Blood Volume in Animal Models

    摘要
  • 摘要:
      目的  通过动物实验论证超声微泡造影技术测量肺血量（pulmonary blood volume, PBV）的可行性及可重复性。
      方法  采用“声诺维”造影剂，利用超声微泡造影技术测量动物模型肺通过时间（pulmonary transit time, PTT）或标准化的肺通过时间（heart rate-normalized pulmonary transit time, nPTT）计算PBV，根据观察者组内、组间变异性，个体观察者日内变异性以探讨其可重复性，通过在急性缺血性左心衰动物模型中的应用以评估其可行性。
      结果  Bland-Atlman法统计结果显示该测量方法测量结果观察者组内一致性、日内一致性和组间一致性均较好；在急性缺血性左心衰动物模型中的应用观察发现：PTT〔（2.67±0.28） s〕较心衰前PTT〔（1.75±0.07） s〕延长，nPTT（6.72±0.57）较心衰前nPTT（3.93±0.16）增加，PBV〔（168.52±21.24） mL〕较心衰前PBV〔（108.79±11.98） mL〕增多，差异均有统计学意义（P<0.05）。
      结论  超声微泡造影技术检测PTT或nPTT计算PBV简易可行，不易产生误判，不同观察者间检测结果一致，重复性检测结果一致性较高；通过该方法测量PTT或nPTT计算并比较PBV的变化具有一定的可行性。

     

    Abstract:
      Objective  To investigate the feasibility of measuring pulmonary blood volume (PBV) by ultrasound microbubble angiography, which may provide a feasible method for further detection of PBV changes.
      Methods  Ultrasound microbubble angiography was used to calculate the PBV by detecting pulmonary transit time (PTT) and heart rate-normalized pulmonary transit time (nPTT). To evaluate the consensus degree based on the intra-, inter-observer and within-day variation in order to determine the repeatability. The method was used for acute left ventricular dysfunction models to determine the feasibility as well.
      Results  The Bland-Atlman plots showed good intra-observer, within-day, and inter-observer consistency of measurement results. Application in acute left ventricular dysfunction models showed that, compared with the control, left heart failure models had higher PTT, nPTT and PBV (P<0.05).
      Conclusion  Detection of PTT/nPTT to calculate PBV by ultrasound microbubble angiography is simple and feasible, it is not easy to produce miscarriage of justice, with good intra- and inter-observer consistency of repeatability test results. The method has certain feasibility.

     

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