Developments in Research on the Relationship Between <i>Porphyromonas gingivalis</i> and Non-Oral Diseases

ZHANG Ke-ke; SUN Yan; PAN Yi-huai

doi:10.12182/20230160509

ZHANG Ke-ke, SUN Yan, PAN Yi-huai. Developments in Research on the Relationship Between Porphyromonas gingivalis and Non-Oral Diseases[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(1): 20-26. DOI: 10.12182/20230160509

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Developments in Research on the Relationship Between Porphyromonas gingivalis and Non-Oral Diseases

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Abstract

Porphyromonas gingivalis (P. gingivalis) is a common periodontal pathogen. Recently, there has been increasing evidence suggesting that P. gingivalis is not only a common pathogen in the oral cavity, but is also closely associated with non-oral diseases, including inflammatory bowel disease, cancer, cardiovascular diseases, Alzheimer's disease, rheumatoid arthritis, diabetes mellitus, premature birth and non-alcoholic hepatitis, etc. Herein, we reviewed the developments in recent years in research on the relationship between P. gingivalis, a periodontal pathogen, and non-oral diseases, which will help determine whether P. gingivalis could be used as an auxiliary diagnostic biomarker or a potential therapeutic target for these non-oral diseases, thus contributing to the development of treatment strategies for the relevant diseases.

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