视神经脊髓炎患者焦虑抑郁与临床特点相关性研究

苗晓慧; 石紫燕; 陈虹西等

栏目: 论著

视神经脊髓炎患者焦虑抑郁与临床特点相关性研究

四川大学华西医院神经内科

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出版历程
- 发布日期: 2017-11-19

Anxiety and Depression in Patients with Neuromyelitis Optica

摘要

摘要: 目的研究视神经脊髓炎(NMO)患者焦虑、抑郁现状及其与临床特点的相关性。方法对符合标准的NMO患者使用汉密尔顿焦虑量表-14（HARS-14）、汉密尔顿抑郁量表-21（HDRS-21）和扩展残疾状况量表（EDSS）进行评分，并分析焦虑、抑郁障碍与临床特点的关系。结果 65例NMO患者（5例男性，60例女性），平均年龄(39.85±10.36)岁，EDSS评分中位数为2.5分，躯体疼痛平均得分为(37.37±20.44)分，血清NMO-IgG阳性比例76.9%。焦虑评分结果平均值为（11.03±6.95）分，抑郁评分结果平均值为(11.74±7.78)分。65例患者中，有焦虑患者占27.69%（18/65），有抑郁患者占24.62（16/65）。单因素分析显示，EDSS评分与焦虑评分（r=0.285, P=0.004）、抑郁评分（r=0.328, P=0.008）呈低度正相关，躯体疼痛与焦虑评分（r=- 0.561, Pr=- 0.496, Pr=0.285, P=0.022）呈低度正相关。年龄、性别、病程、NMO-IgG对患者焦虑、抑郁均无影响。Logistic回归分析显示，躯体疼痛是NMO患者焦虑、抑郁的主要危险因素（比值比分别为1.052、1.046， P<0.05）。结论 NMO患者残疾状态与焦虑、抑郁均相关，发作次数与焦虑相关，躯体疼痛是NMO患者焦虑、抑郁的主要危险因素。
- 视神经脊髓炎焦虑抑郁躯体疼痛
Abstract: ObjectiveTo assess anxiety and depression in patients with neuromyelitis optica (NMO). MethodsEligible patients with NMO were assessed with Hamilton anxiety rating scale-14 (HARS-14), Hamilton depression rating scale-21 (HDRS-21) and expanded disability status scale (EDSS). ResultsA total of 65 NMO patients 〔(39.85±10.36) yr.，male/female: 5/60) participated in this study. They had a median EDSS score of 2.5 and a mean score of (37.37±20.44) for bodily pain. About 76.9% of patients were NMO-IgG seropositive. The participants had (11.03±6.95) HARS-14 scores and (11.74±7.78) HDRS-21 scores, with 27.69% (18/65) being diagnosed with anxiety and 24.62% (16/65) being depressed. The EDSS scores were correlated with HARS-14 scores (r=0.285, P=0.004) and HDRS-21 scores (r=0.328, P=0.008). Bodily pain was negatively correlated with HARS-14 scores (r=-0.561, Pr=-0.496, Pr=0.285, P=0.022). Age, sex, duration of disease, and serum NMO-IgG were not correlated with HARS-14 scores and HDRS-21 scores. The logistic regression model identified bodily pain as a predictor of anxiety and depression in NMO patients (OR=1.052, 1.046, respectively, P<0.05). ConclusionDisability and bodily pain are associated with anxiety and depression in NMO patients, while relapse is associated with anxiety only. Bodily pain is a predictor of anxiety and depression in NMO patients.
- Neuromyelitis opticaAnxietyDepressionBodily pain