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住院儿童分离的金黄色葡萄球菌临床分布及耐药性分析

邓建军, 朱佳妮, 杨晨璐, 舒敏, 肖国光, 苏敏, 周伟

邓建军, 朱佳妮, 杨晨璐, 等. 住院儿童分离的金黄色葡萄球菌临床分布及耐药性分析[J]. 四川大学学报（医学版）, 2013, 44(1): 159-161.
引用本文: 邓建军, 朱佳妮, 杨晨璐, 等. 住院儿童分离的金黄色葡萄球菌临床分布及耐药性分析[J]. 四川大学学报（医学版）, 2013, 44(1): 159-161.
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DENG Jian-jun, ZHU Jia-ni, YANG Chen-lu, et al. Clinical Distribution and Drug Resistance of Staphylococcus Aureus Isolated from Hospitalized Children[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(1): 159-161.
Citation: DENG Jian-jun, ZHU Jia-ni, YANG Chen-lu, et al. Clinical Distribution and Drug Resistance of Staphylococcus Aureus Isolated from Hospitalized Children[J]. Journal of Sichuan University (Medical Sciences), 2013, 44(1): 159-161.
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栏目: 临床医学

住院儿童分离的金黄色葡萄球菌临床分布及耐药性分析

  • 1. 四川大学华西第二医院 儿科(成都 610041);

  • 2. 四川大学华西公共卫生学院(成都 610041);

  • 3. 四川大学华西第二医院 临床微生物室(成都 610041)

Clinical Distribution and Drug Resistance of Staphylococcus Aureus Isolated from Hospitalized Children

  • 1. Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China;

  • 2. West China School of Public Health, Sichuan University, Chengdu 610041, China;

  • 3. Clinical Microbiology Laboratory, West China Second Hospital, Sichuan University, Chengdu 610041, China

摘要

    摘要
  • 摘要: 目的 了解临床分离的金黄色葡萄球菌的临床分布情况及耐药情况,为临床合理用药提供依据。 方法 总结近2年我院分离的金黄色葡萄球菌的临床特征及药敏试验结果。 结果 近2年我院共分离金黄色葡萄球菌248株,最常见的病种为金黄色葡萄球菌肺炎163例,其次是皮肤感染21例,败血症11例,临床常用苯唑西林、萘夫西林、头孢硫脒、万古霉素等抗生素治疗,平均抗生素疗程为12.48 d,肺炎及败血症的疗程较长,分别达到13.71 d及15.11 d,96.31%(235/244)的金黄色葡萄球菌对青霉素耐药,耐甲氧西林金黄色葡萄球菌占14.34%(35/242),未发现耐万古霉素的金葡菌。 结论 金黄色葡萄球菌肺炎是感染金黄色葡萄球菌儿童住院首要病因,抗感染疗程较长,对常用抗生素具有较高耐药率,应引起高度重视。

     

    Abstract: Objective To learn about the clinical distribution and drug resistance of Staphylococcus aureus (S.aureus) isolated from inpatients and provide evidence for clinically reasonable use of antibiotics. Methods Data including clinical features and drug sensitivity of S.aureus isolated from hospitalized patients in the last two years were analyzed. Results 248 S.aureus strains were isolated from inpatients of our hospital in the last 2 years. The most common disease caused by S.aureus was pneumonia with a total of 163 patients. The second was skin and soft tissue infection with 21 patients in total. Sepsis occurred in 11 patients.The most commonly used antibiotics included oxacillin, nafcillin, cefathiamidine and vancomycin. The average course of antibiotic was 12.48 days. Treatment course of pneumonia and sepsis was 13.71 and 15.11 respectively. 96.31% (235/244) of S.aureus were resistant to penicillin. Vancomycin-resistant S.aureus has not been isolated. Conclusion S.aureus pneumonia is the leading cause of hospitalization of children with S.aureus infection. S.aureus is highly resistant to commonly used antibiotics and related infections need longer therapy. Clinicians should pay more attention to S.aureus infection.

     

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  • [1]

    Lamaro-Cardoso J, de Lencastre H, Kipnis A, et al. Molecular epidemiology and risk factors for nasal carriage of Staphylococcus aureus and methicillin-resistant S.aureus in infants attending day care centers in Brazil. J Clin Microbiol,2009;47(12):3991-3997.
    [2]

    Alfadhel M, Puapermpoonsiri U, Ford SJ, et al. Lyophilized inserts for nasal administration harboring bacteriophage selective for Staphylococcus aureus: in vitro evaluation. Int J Pharm,2011;416(1):280-287.
    [3]

    Ena J, Boelaert JR, Boyken LD,et al. Epidemiology of Staphylococcus aureus infections in patients on hemodialysis. Infect Control Hosp Epidemiol,1994;15(2):78-81.
    [4]

    Budimir A, Deurenberg RH, Plecko V, et al. Molecular characterization of methicillin-resistant Staphylococcus aureus bloodstream isolates from Croatia. J Antimicrob Chemother,2006;57(2):331-334.
    [5] 胡英惠, 甄景慧, 赵德环.小儿社区获得性耐甲氧西林金黄色葡萄球菌感染临床分析.中国当代儿科杂志,2006;8(4):298-300.
    [6] 汪 玲, 陆 权, 王传清等.2000~2004年京沪穗渝5家儿童医院革兰氏阳性球菌耐药情况分析.中国循征儿科杂志,2006;1(2):113-120.
    [7] 王清涛, 杜小玲, 曲寿山等.金黄色葡萄球菌耐药性分析.中华医学检验杂志,1996;19(2):186-188.
    [8]

    Bartley J. First case of VRSA identified in Michigan. Infect Control Hosp Epidemiol,2002;23(8):480.
    [9] 毕少杰, 于 晶, 刘 婷等.济南地区异质性万古霉素中介金葡菌的分离率及方法研究. 山东大学学报(医学版),2010;48(6):41-44.
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出版历程
  • 收稿日期:  2012-07-02
  • 修回日期:  2012-10-25
  • 发布日期:  2013-01-19

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