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Prevalence Survey of Functional Dyspepsia and Irritable Bowel Syndrome in Chinese College Students Based on Rome Ⅳ Diagnostic Criteria
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摘要:
目的 了解我国高校学生功能性消化不良（functional dyspepsia, FD）、肠易激综合征（irritable bowel syndrome, IBS）的患病率及危险因素。 方法 本研究采用网络电子问卷为主联合现场调查为辅的调查方法，对17～35岁之间的中国各地高校学生进行在线问卷调查, 最终纳入2025份有效问卷进行统计分析。统计学方法采用χ2检验和logistic回归。 结果 符合罗马Ⅳ标准高校学生FD患病率为5.5%（112/2025），以餐后不适综合征（postprandial distress syndrome, PDS）（66.1%，74/112）为主，吸烟〔比值比（OR）=2.334，95%置信区间（CI）：1.187～4.589, P=0.014〕、抑郁（OR=2.447，95%CI：1.421～4.214, P=0.001）、失眠（OR=1.947，95%CI：1.291～2.937, P=0.001）与FD患病呈正相关。IBS患病率为1.9%（38/2025），以腹泻型（diarrhea-predominant IBS, IBS-D）为主（44.7%），焦虑（OR=3.63，95%CI：1.34～9.88，P=0.012）、失眠（OR=2.35，95%CI：1.18～4.68, P=0.015）与IBS患病呈正相关。 结论 基于罗马Ⅳ标准，IBS、FD在中国高校学生中患病并不少见，心理障碍和一些相关的生活方式因素可能与疾病发展有关，未来应该在中国开展更多基于不同诊断标准、不同地域、多因素的系列研究。 Abstract:Objective To investigate the prevalence and risk factors of functional dyspepsia (FD) and irritable bowel syndrome (IBS) among college students in China. Methods An online questionnaire survey of college students aged 17-35 from across China was conducted. The online questionnaire survey was supplemented by an offline survey. A total of 2025 valid samples were included for statistical analysis. χ2 test and logistic regression were performed for statistical analysis. Results The prevalence of FD among college students who met the Rome Ⅳ diagnostic criteria was 5.5% (112/2025), with most of them, or 66.1% (74/112), suffering from postprandial discomfort syndrome (PDS). Smoking (odds ratio [OR]=2.334, 95% confidence interval [CI]: 1.187-4.589, P=0.014), depression (OR=2.447, 95% CI: 1.421-4.214, P=0.001), and insomnia (OR=1.947, 95% CI: 1.291-2.937, P=0.001) were positively correlated with the prevalence of FD. The prevalence of IBS was 1.9% (38/2025), with IBS-diarrhea dominant (IBS-D) being the most important subtype that accounted for 44.7%. Anxiety (OR=3.63, 95% CI: 1.34-9.88, P=0.012) and insomnia (OR=2.35, 95% CI: 1.18-4.68, P=0.015) were positively correlated with the prevalence of IBS. Conclusion Based on Rome Ⅳ criteria, IBS and FD are not uncommon among Chinese university students. Psychological disorders and some related lifestyle factors may be related to the development of the disease. In the future, more series of studies based on different diagnostic criteria, different regions, and multiple factors should be conducted in China. -
Key words:
- Functional dyspepsia /
- Irritable bowel syndrome /
- Rome Ⅳ /
- Prevalence survey /
- Risk factors
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表 1 FD、IBS的患病情况调查结果（单选题）
Table 1. Results for FD and IBS prevalence survey (single-choice questions)
Factor Variable Non-FD group
(n=1913)FD group
(n=112)P Non-IBS group
(n=1987)IBS group
(n=38)P Sex Male 690 43 0.619 716 17 0.269 Female 1223 69 1271 21 Age/yr. 17-23 1196 65 0.306 1231 30 0.090 24-29 683 43 718 8 30-35 34 4 38 0 BMI Underweight 314 12 0.311 324 2 0.127 Normal 1397 84 1452 29 Overweight 191 15 199 7 Obesity 11 1 12 0 Grade First year 204 10 0.243 208 6 0.799 Second year 256 14 265 5 Third year 281 12 287 6 Fourth year 256 24 273 7 Fifth year 115 10 124 1 Master's student 677 37 702 12 Doctoral student 124 5 128 1 Major Economics and management 193 11 0.259 201 3 0.170 Science and engineering 469 27 489 7 Literature and history 93 1 92 2 Politics and law 61 2 63 0 Arts 26 3 27 2 Sports 16 3 17 2 Languages 25 2 26 1 Medicine 997 62 1040 19 Agriculture 33 1 32 2 Being the only child of the family No 1168 64 0.410 1214 18 0.086 Yes 745 48 773 20 Smoking No 1835 101 0.008 1899 37 0.892 Yes 78 11 88 1 Drinking No 1788 97 0.005 1849 36 0.935 Yes 125 15 138 2 Regular mealtime Very regular 332 11 0.017 336 7 0.886 More regular 1200 68 1243 25 Regular 157 17 171 3 Irregular 224 16 237 3 Breakfast frequency Daily 838 43 0.279 867 14 0.215 4-6 times/week 550 38 572 16 1-3 times/week 442 23 457 8 Always skipping breakfast 83 8 91 0 Dietary attitude Taste first 536 26 0.051 550 12 0.883 Satiety first 293 27 313 7 Nutrition first 340 14 348 6 Occasional balanced diet 744 45 776 13 Mobile phone addiction No 455 13 0.003 467 1 0.003 Yes 1458 99 1520 37 Anxiety No 967 32 0.000 994 5 0.000 Yes 946 80 993 33 Depression No 722 18 0.000 736 4 0.001 Yes 1191 94 1251 34 Insomnia No 1280 52 0.000 1323 9 0.000 Yes 633 60 664 29 
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表 2 FD、IBS的患病情况调查结果（多选题）
Table 2. Results for FD and IBS prevalence survey (multiple-choice questions)
Factor Variable Non-FD group (n=1913) FD group (n=112) P Non-IBS group (n=1987) IBS group (n=38) P Beverage preferences Bubble tea 616 39 0.186 641 14 0.847 Fruit juices 740 46 772 14 Coffee 285 21 298 8 Carbonated drinks 501 32 520 13 Water 1187 56 1218 25 Tea 486 34 509 11 Milk or yogurt 456 28 474 10 Dietary preferences Uncooked or unheated food 213 22 0.001 231 4 0.635 Spicy food 967 65 1010 22 Deep-fried food 535 47 567 15 Cheese 709 47 742 14 Fruit 1308 75 1360 23 Vegetable 1237 68 1282 23 Source of stress Family 836 56 0.614 876 16 0.874 Interpersonal relations 788 47 821 14 Career 850 55 891 14 Studies 1554 94 1618 30 Romantic relationship 382 23 399 6 Personal health 736 47 769 14 Mood 953 63 996 20 Adaptation 474 32 500 6
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