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田而慷, 王玥, 吴卓轩, 等. 噬菌体疗法:回顾与展望[J]. 四川大学学报(医学版), 2021, 52(2): 170-175. DOI: 10.12182/20210360207
引用本文: 田而慷, 王玥, 吴卓轩, 等. 噬菌体疗法:回顾与展望[J]. 四川大学学报(医学版), 2021, 52(2): 170-175. DOI: 10.12182/20210360207
TIAN Er-kang, WANG Yue, WU Zhuo-xuan, et al. Bacteriophage Therapy: Retrospective Review and Future Prospects[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(2): 170-175. DOI: 10.12182/20210360207
Citation: TIAN Er-kang, WANG Yue, WU Zhuo-xuan, et al. Bacteriophage Therapy: Retrospective Review and Future Prospects[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(2): 170-175. DOI: 10.12182/20210360207

噬菌体疗法:回顾与展望

Bacteriophage Therapy: Retrospective Review and Future Prospects

  • 摘要: 目前,细菌感染的治疗主要使用抗生素,但随着抗生素耐药性问题越发严重,迫切需要新的治疗方法。因此,噬菌体疗法将是解决细菌耐药性的一种潜在选择,并可考虑噬菌体与抗生素联合治疗。遗憾的是,目前缺乏设计良好的噬菌体疗法临床对照试验,希望未来有更多的研究着眼于解决噬菌体疗法抗菌谱窄、安全性未知和细菌抵抗等问题。部分难治性疾病如乳腺癌和酒精性肝炎在临床治疗上也较难处理,噬菌体在这些领域成功的实验研究报道给未来更多的难治性疾病提供了新的治疗思路。除此之外,噬菌体在疫苗应用和骨再生中也有不错的表现。本文综述了上述噬菌体疗法在相关疾病的应用及其治疗机制。最后,通过对噬菌体疗法现存不足进行总结,并对其在系统性疾病中的应用前景进行展望,以期能进一步推动对噬菌体疗法的临床应用研究。

     

    Abstract: At present, bacterial infections are mainly treated with antibiotics, but new treatment methods are urgently needed because of growing problems with antibiotic resistance. Therefore, phage therapy will be a potential solution to the problem of bacterial drug resistance, and the combined use of bacteriophage and antibiotics is also considered a potential treatment option. However, there has not been any well-designed clinical controlled trials on phage therapy. More future research needs to be done to solve the problems of phage therapy, for example, its narrow antibacterial spectrum, the uncertainty regarding treatment safety, and the bacterial resistance. Some refractory diseases such as breast cancer and alcoholic hepatitis are difficult to treat clinically. The successful experimental research on bacteriophages reported in these fields provides new ideas of treatment for more refractory diseases in the future. In addition, bacteriophages also showed promising performance in vaccine applications and osteanagenesis. We herein summarize the existing weaknesses of phage therapy and its application prospects in treating systemic diseases, hoping to promote further clinical application research of phage therapy.

     

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